Tau Proteins Spread More Easily In The Aging Brain

P301Ltau misfolding
Certain molecules involved in Alzheimer's disease called tau-proteins spread more easily in the aging brain, new research in mice from German investigators suggests. The study was carried out in collaboration with researchers in the US at Harvard Medical School and Massachusetts General Hospital. Alzheimer’s disease usually begins with memory decline and later affects other cognitive …

Autism May Stem from Genetic Defect During Scaffolding Of Developing Brain

Tiling of Radial Glial Cells
A gene mutation associated with autism spectrum disorders normally works to organize the scaffolding of brain cells called radial progenitors necessary for the orderly formation of the brain, report scientists from University of North Carolina at Chapel Hill School of Medicine. The finding sheds light on the molecular details of a key process in brain …

E-cigarettes Cause Stress-induced Damage In Neural Stem Cells

vaping
Electronic cigarettes, often targeted to youth and pregnant women, cause a stress response in neural stem cells, critical cells in the brain, reports a research team at the University of California, Riverside. Using cultured mouse neural stem cells, the UC Riverside researchers identified the mechanism underlying electronic cigarette-induced stem cell toxicity as "stress-induced mitochondrial hyperfusion," …

Alzheimer’s: Microglia Have Key Role In Proliferation Of Tau Pathologies

TREM2 function impedes tau seeding in neuritic plaques
The link between amyloid beta and tau may lie in the brain's immune cells that hem in clumps of amyloid, researchers at Washington University School of Medicine in St. Louis have found. If the immune cells falter, amyloid clumps, or plaques, injure nearby neurons and create a toxic environment that accelerates the formation and spread …

Neurotechnology-based Interventions For Upper Limb Motor Rehabilitation

Neurotechnology-aided interventions for upper limb motor rehabilitation in severe chronic stroke
A recently published paper calls for longitudinal clinical studies to show the stroke rehabilitation benefits of individual therapies as well as the use of multiple complementary therapies used in combination over long time periods. Personalized neurotechnology-aided rehabilitation of the arm could improve recovery in severe chronic stroke patients according to the paper. Neurotechnology-based therapies, including …

Parkinson’s Disease Propagates From Gut Cells Via The Vagus Nerve

parkinsons
A new study offers a more accurate model in which to test treatments that could prevent or halt Parkinson's disease progression. In experiments in mice, Johns Hopkins Medicine researchers report they found additional evidence that Parkinson's disease originates among cells in the gut and travels up the body's neurons to the brain. "These findings provide …

Early Role Of Serotonergic Pathology In Parkinson’s Disease Highlighted

parkisnons sertonergic pathology
The earliest signs of Parkinson's disease in the brain, many years before patients show any symptoms, have been uncovered by researchers from King's College London. The results suggest changes to the serotonin system could act as a key early warning signal for the disease. "Parkinson's disease has traditionally been thought of as occurring due to …

New Research Could Help Predict Epilepsy Seizures Before They Happen

Dr Marion Hogg
A pattern of molecules that appear in the blood before a seizure happens has been discovered by researchers at the Royal College of Surgeons in Ireland. The finding may lead to the development of an early warning system, which would enable people with temporal lobe epilepsy to know when they are at risk of having …