Neuroscience

Neurons that regularly remodel are more prone to Alzheimer’s disease and die when that remodeling goes awry, a new study suggests. The work is the first to track the progression of Alzheimer’s at the genetic and molecular levels within neurons vulnerable to the disease. “Identifying the molecular characteristics of neurons that are especially vulnerable to… Read more

The world around us is constantly changing. As seasons shift, or as night turns to day, and food becomes more or less available, every organism must adapt their behavior and physiology to cope with its changing environment. The neuroendocrine systems play a central role in converting signals from the environment into biomolecules that can generate… Read more

How old are you? What about your body, and your brain? People are used to answering this question by counting the years since birth. However, biological age could also be measured by looking at the integrity of the DNA in cells or by measuring the levels of proteins in the blood. Whether one goes by… Read more

A well-trained athlete sprinting 100 yards performs a highly stereotyped, repetitive motor pattern. Neuroscientists understand that these rhythmic motor programs, such as walking, swimming and running, are produced by neural circuitry that generates repetitive patterns that are similar from cycle to cycle. Over a century ago, spinal cord experiments led to the proposal that a… Read more

The human brain is bathed in a supportive fluid called the cerebrospinal fluid (CSF) that provides nutrients and is required for proper brain function. The composition of human CSF and how it is made are poorly understood due to a lack of experimental access. Madeline Lancaster’s group in the Medical Research Council of England’s Laboratory… Read more