The compound LSL60101 improved cognitive deficit and biomarkers related to Alzheimer’s disease in studies carried out with mice. The work is described in a paper1 detailing the synthesis of a new family of compounds with high affinity and selectivity for imidazoline I2 receptors, altered in the brain of patients with Alzheimer’s. The synthesis pathway of compounds is efficient and affordable. It would allow different structural modifications to access a range of compounds of pharmaceutical interest.
Intelligence and good decision-making don’t always go together. Even the smartest people are capable of making some pretty foolish decisions. Decision-making is another one of those things that should be taught in schools. It would probably prove to be a more useful skill than precalculus in the typical day of most people. Credit: Unsplash/CC0 It only takes a few bad decisions to mess up your life if those decisions are critical enough.
A novel biomarker indicating resilience to chronic stress has been found by researchers. This biomarker is largely absent in people suffering from major depressive disorder, and this absence is further associated with pessimism in daily life, their new study1 finds. To our knowledge, this is the first work to show that glutamate in the human medial prefrontal cortex shows an adaptive habituation to a new stressful experience if someone has recently experienced a lot of stress.
By identifying a possible novel cellular mechanism for migraines, researchers may have also found a new way to treat chronic migraine. The goal of the research1 was to find a new mechanism of chronic migraine and propose a cellular pathway for migraine therapies. Senior author Amynah Pradhan is associate professor of psychiatry at the University of Illinois Chicago. He explained that the dynamic process of routing and rerouting connections among nerve cells, called neural plasticity, is critical to both the causes and cures for disorders of the central nervous system such as depression, chronic pain, and addiction.
Women suffer severe COVID-19 at around half the rate as men, but the reason for this has been unclear. Now, research1 has found that women have different levels of mucosal associated invariant T cells, and these immune cells amass in the lungs, poised to attack the COVID virus. Better armed with these specialized immune cells, women appear to be more equipped to fight some of the most severe impacts of COVID-19, notably the respiratory infections that can become life-threatening,
Staufen1, a protein that accumulates in the brains of patients with certain neurological conditions, is linked to amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, along with other neurological disorders, including Alzheimer’s, Parkinson’s, and Huntington’s disease, University of Utah Health scientists report. Credit: Unsplash/CC0 The findings1 connect Staufen1 to the emerging concept that neurodegenerative diseases are linked to malfunctions in the way cells cope with cellular stress.
An extensive push to identify and validate blood biomarkers for mood disorders has resulted in a blood test, composed of RNA biomarkers, that can distinguish how severe a patient’s depression is. The test also can predict their risk of severe depression in the future, and their risk of future bipolar disorder, or manic-depressive illness, as well as informs tailored medication choices for patients. The work1 builds on previous research into blood biomarkers2 that track suicidality as well as pain, post-traumatic stress disorder, and Alzheimer’s disease3.
People with early-onset dementia are often misdiagnosed as having depression. Research has now identified what may actually be happening in such cases: a profound loss of ability to experience pleasure. The loss is related to degeneration of ‘hedonic hotspots’ in the brain where pleasure mechanisms are concentrated, University of Sydney-led research1 shows. The study revealed marked degeneration, or atrophy, of grey matter in frontal and striatal areas of the brain related to diminished reward-seeking, in patients with frontotemporal dementia (FTD).