Vasomotion, the spontaneous oscillation in tone of blood vessel walls, independent of heart beat, innervation or respiration, pushes the clearance of substances from the brain, investigators at Massachusetts General Hospital (MGH) have found. The findings suggest that targeting and enhancing this process may promote prevention or treatment of amyloid-beta accumulation. In Alzheimer’s disease, amyloid-beta protein… Read more

Drugs that quell inflammation in the brain could slow or even reverse the cognitive decline that comes with age. Senile mice given one such drug had fewer signs of brain inflammation and were better able to learn new tasks, becoming almost as adept as mice half their age. “We tend to think about the aged… Read more

Researchers at Vanderbilt University Medical Center traveled down the pathways in the brains of mice that trigger fear responses, and which normally extinguish the behaviors once the danger has passed, in order to explore how fear becomes entrenched. Their scientific journey, detailed recently in Nature Neuroscience[1], challenges conventional wisdom about how the brain is “remodeled”… Read more

Exposure to cadmium, a known human carcinogen, even at levels found in people who do not smoke cigarettes, leads to accelerated cognitive impairment, according to a new animal study. Those with genetic risk of developing Alzheimer’s disease, particularly males, are most vulnerable to the adverse health effects, the study suggests. “This heavy metal is bad… Read more

Pepi Nana stirs, and sits up in bed. “Tiddle toddle, tiddle toddle,” she says, flapping her arms, and blinking a pair of enormous round eyes. She walks over to the desk, sits down, and, using the oversized pencil in her front pocket, scribbles a letter to the Moon. “Tiddle toddle, please come to tea, and… Read more