Augmenting MRI-based Alzheimer’s Disease Classification With AI

Using a generative adversarial network, an advanced artificial intelligence framework based on game theory, researchers at Boston University School of Medicine processed brain images to generate a model that was able to classify Alzheimer’s disease with improved accuracy. Improving the diagnostic accuracy of Alzheimer’s disease is an important clinical goal. If we are able to…

EGFL8 Signaling Molecule Stops Malignant Neuroblastoma Tumors

The uncontrolled growth of benign neuroblastomas is stopped by a signal molecule produced by Schwann cells present within these tumors, new research has found. This naturally occuring “brake” also works on malignant neuroblastoma cultures, according to scientists at St. Anna Children’s Cancer Research Institute. Together with colleagues from the Medical University of Vienna and the…

What Is Calicheamicin?

The calicheamicins are a class of enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora, with calicheamicin γ1 being the most notable. It was isolated originally in the mid-1980s from the chalky soil, or “caliche pits”, located in Kerrville, Texas. The sample was collected by a scientist employed by Lederle Labs (now part of Pfizer)…

Toddlers With Erratic Sleep Patterns Have Higher Body Mass Index

New research from University of Delaware links inconsistent sleep times to higher body mass index (BMI) percentiles. The findings suggest sleep may help explain the association between household poverty and BMI. We’ve known for a while that physical activity and diet quality are very strong predictors of weight and BMI. I think it’s really highlighting…

Prolonged Medically Induced Coma Alters Brain Connectivity

Prolonged anesthesia significantly alters the synaptic architecture of the brain regardless of age, according to new research. Prolonged anesthesia, also known as medically induced coma, is a life-saving procedure carried out across the globe on millions of patients in intensive medical care units every year. Unfortunately, after this type of coma, which takes the brain…

Hippocampus Place Cells Use Rate And Phase Code For Route Finding

Pyramidal neurons in the hippocampus inscribe spatial information using two interchangeable information processing methods referred to as a rate code and a phase code, that can be roughly compared to the number and spatial arrangement of bar codes, The Korea Institute of Science and Technology (KIST) reports. The research team, led by Sebastien Royer at…

What Is Molecularly Targeted Therapy?

Molecularly targeted therapy, or targeted therapy, is one of the major modalities of medical treatment for cancer, others being hormonal therapy and cytotoxic chemotherapy. As a form of molecular medicine, targeted therapy blocks the growth of cancer cells by interfering with specific targeted molecules needed for carcinogenesis and tumor growth, rather than by simply interfering…

Decoding Vision With High-density Diffuse Optical Tomography Brain Imaging

New research shows that light can be used to detect what is going on inside someone’s head and identify what image they are seeing. The study1 demonstrates that high-density diffuse optical tomography (HD-DOT) – a noninvasive, wearable, light-based brain imaging technology – is sufficiently sensitive and precise to be potentially useful in applications such as…