What Is Dermatofibrosarcoma Protuberans?

Dermatofibrosarcoma protuberans (DFSP) is a rare locally aggressive malignant cutaneous soft-tissue sarcoma. DFSP develops in the connective tissue cells in the middle layer of the skin (dermis). Estimates of the overall occurrence of dermatofibrosarcoma protuberans in the United States are 0.8 to 4.5 cases per million persons per year. In the United States, DFSP accounts…

BAF Complex Inhibition Induces Fast Loss Of DNA Accessibility

Silencing BAF complex function results in almost a total loss of chromatin accessibility at BAF-controlled sites, a new paper1 has found. When human cells need to acclimate to a various external influences, the BRG1/BRM-associated factor (BAF) complex is central to the process – it regulates the accessibility of the DNA and the information stored in…

Low-dose ISRIB Restores Protein Synthesis And Cognition

A possible way to address loss of cognitive function due to Alzheimer’s disease by targeting protein synthesis has been identified by researchers. The findings1 show that synthetic pharmaceuticals could rescue the activity of brain cells needed for memory formation. This work is the first to show that reversing impaired protein synthesis in brains afflicted by…

Immune Hubs In The Meninges Enable Central Nervous System Immunosurveillance

Immune cells fill pockets in the outer layer of the meninges — the tissue that covers the brain and spinal cord — where they sample cerebrospinal fluid as it washes out of the brain, a new study finds. If the cells detect signs of infection, disease, or injury, they are prepared to initiate an immune…

Amygdala Connectivity Changes After Exposure Therapy For PTSD

A new neuroimaging study investigates how psychotherapy for people with PTSD changes the brain areas responsible for generating emotional responses to threats used. Trauma-focused psychotherapy is considered the best available treatment for post-traumatic stress disorder (PTSD). However, the ways in which this method affects the brain to promote recovery from PTSD are not well understood.…

G3BPs At The Lysosomal Surface Inhibit mTORC1

The signaling protein mTOR (Mechanistic Target of Rapamycin) is a sensor for nutrients such as amino acids and sugars. When sufficient nutrients are available, mTOR boosts metabolism and ensures that sufficient energy and cellular building blocks are available. Since mTOR is a central switch for metabolism, errors in its activation lead to serious diseases. Cancers…

Oleic Acid In Diet Could Help Against Multiple Sclerosis

Lack of a specific fatty acid in fat tissue can trigger the abnormal immune system response that causes multiple sclerosis (MS) by attacking and damaging the central nervous system, according to a new study1. Fat tissue in patients diagnosed with MS were found to have abnormal levels of oleic acid, a monounsaturated fatty acid found…

What Is Gefitinib?

Gefitinib, sold under the brand name Iressa by AstraZeneca and Teva, is a medication used for certain breast, lung and other cancers. Gefitinib is an EGFR inhibitor, interrupting signaling through the epidermal growth factor receptor (EGFR) in target cells. As such, it is only effective in cancers with mutated and overactive EGFR, but resistances to…