Adult Astrocytes Are Key To Learning And Memory

Astrocytes, the most abundant cells in the brain, play a direct role in the regulation of neuronal circuits involved in learning and memory, researchers at Baylor College of Medicine report[1]. “It has become increasingly clear that astrocytes are much more than supportive cells in the healthy adult brain. They play a direct role in a…

Lithium May Treat Behavior Linked To Autism Gene

The mood-stabilizing drug lithium eases repetitive behaviors seen in mice missing SHANK3, an autism gene, according to a new study. The findings[1] suggest lithium merits further study as a treatment for some people with autism, even though the drug has troublesome side effects, including tremors and impaired memory. “Lithium is, of course, a rather difficult,…

Infant Temperament Predicts Personality More Than 20 Years Later

Researchers investigating how temperament shapes adult life-course outcomes have found that behavioral inhibition in infancy predicts a reserved, introverted personality at age 26. For those individuals who show sensitivity to making errors in adolescence, the findings indicated a higher risk for internalizing disorders (such as anxiety and depression) in adulthood. The study[1] provides robust evidence…

Crizotinib

Crizotinib (trade name Xalkori) is an anti-cancer medication acting as an anaplastic lymphoma kinase (ALK) and ROS1 (c-ros oncogene 1) inhibitor. It is approved for treatment of some non-small cell lung carcinoma (NSCLC) in the US and other countries. Mechanism Crizotinib has an aminopyridine structure1, and functions as a protein kinase inhibitor by competitive binding…

Concussions Linked To Loss Of Inhibition

Lowered inhibition found in one study of concussion sufferers were mirrored in separate tests on Canadian university football players. The findings open new doors to predicting the impact of the often debilitating injury, as well as raise questions about the long-term impact of contact sports, according to researchers. Led by graduate student Clara Stafford, the…

Brain Function Changes Linked To Genetic Risk In ADHD Diagnosis

New research combines genetics and functional brain imaging to find that both genetic and neural factors influence attention-deficit/hyperactivity disorder (ADHD) diagnosis. Genetic studies of attention-deficit/hyperactivity disorder (ADHD) show that it takes many common genetic variations combining together in one individual to increase risk substantially. At the same time, neuroimaging experts have found differences in how…

The Psychology Of Comfort Food – Why We Look To Carbs For Solace

Amid the global spread of COVID-19 we are witnessing an increased focus on gathering food and supplies. We’ve seen images of supermarket shelves emptied of basics such as toilet paper, pasta, and tinned foods. Messages to reassure people there would be continued supply of provisions has done little to ease public anxiety. Panic buying and…

Whole Genome Sequencing Reveals Genetic Structural Secrets Of Schizophrenia

The University of North Carolina scientists have conducted the largest-ever whole genome sequencing study of schizophrenia to provide a more complete picture of the role the human genome plays in this disease. “Our results suggest that ultra-rare structural variants that affect the boundaries of a specific genome structure increase risk for schizophrenia. Alterations in these…