Synaptic Variability Provides Adaptability For Rhythmic Motor Pattern

A well-trained athlete sprinting 100 yards performs a highly stereotyped, repetitive motor pattern. Neuroscientists understand that these rhythmic motor programs, such as walking, swimming and running, are produced by neural circuitry that generates repetitive patterns that are similar from cycle to cycle. Over a century ago, spinal cord experiments led to the proposal that a simple neural network can produce such a rhythmic oscillatory firing pattern. These oscillatory networks are now known as central pattern generators.

10 Healthy Ways To Manage Your Anger In Your Relationship

Anger is a healthy and natural human emotion that can occur during a relationship, often due to frustration and feelings of being overwhelmed. Unfortunately, failure to control your anger can lead to ugly confrontations that can ruin a once healthy relationship. Follow these strategies for healthy anger management: 1. Calm Down Before you attempt to talk to your partner, take a few moments away from the situation to clear your mind.

Nerve-blocking Antibody Relieves Chronic Low Back Pain

Tanezumab, a monoclonal antibody that inhibits nerve activity, may provide relief to people with chronic low back pain, new research indicates. Chronic low back pain is one of the leading reasons why people seek medical care and the number one cause of disability worldwide. “This demonstration of efficacy is a major breakthrough in the global search to develop non-opioid treatments for chronic pain. There were also improvements in function linked to the reduction in pain severity,” says John Markman, director of the Translational Pain Research Program in neurosurgery department at the University of Rochester Medical Center (URMC) and lead author of the study[1].

What Is Nilotinib?

Nilotinib (brand name Tasigna) is an oral medication used to treat chronic myelogenous leukemia (CML) which has the Philadelphia chromosome. It may be used both in initial cases of chronic phase CML as well as in accelerated and chronic phase CML that has not responded to imatinib. Nilotinib is a Bcr-Abl tyrosine kinase inhibitor and works by interfering with signalling within the cancer cell. It was approved for medical use in the United States in 2007.

Bioelectric Signals Improve Understanding Of Breast Cancer Metastasis

Biologists from Lawrence Livermore National Laboratory (LLNL) have identified a distinct mechanism that affects the maintenance and expansion of malignant cells: electric signals in the tumor microenvironment. Metastasis accounts for approximately 90 percent of mortality in breast cancer patients. During the last few decades, there has been significant progress in understanding genetic, molecular and signaling mechanisms underpinning cancer cell migration. All cells can generate bioelectric signals through their plasma membrane, and therefore naturally exist in our bodies.

Air Quality Impacts Early Brain Development

A link between traffic-related air pollution and an increased risk for changes in brain development relevant to neurodevelopmental disorders has been identified by researchers at the University of California, Davis. Their study[1], based on rodent models, agrees with previous epidemiological evidence showing this association. While air pollution has long been a concern for pulmonary and cardiovascular health, it has only been within the past decade that scientists have turned their attention to its effects on the brain, said UC Davis toxicologist Pamela Lein, senior author of the study.

Study Sheds Light On A Classic Visual Illusion

It’s a classic visual illusion: Two gray dots appear on a background that consists of a gradient from light gray to black. Although the two dots are identical, they appear very different based on where they are placed against the background. Scientists who study the brain have been trying to figure out the mechanism behind this illusion, known as simultaneous brightness contrast, for more than 100 years. An MIT-led study[1] now suggests that this phenomenon relies on brightness estimation that takes place before visual information reaches the brain’s visual cortex, possibly within the retina.


Dasatinib (brand name Sprycel) is a a tyrosine-kinase inhibitor medication used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Specifically it is used to treat cases that are Philadelphia chromosome-positive (Ph+). Dasatinib was approved for medical use in the United States and in the European Union in 2006. The main targets of dasatinib are BCR/Abl (the “Philadelphia chromosome”), Src, c-Kit, ephrin receptors, and several other tyrosine kinases1.