New neurons produced in adults react preferentially to reward-related sensory stimuli and help speed up the association between sensory information and reward, scientists from the Institut Pasteur and the CNRS have shown.
Adult-born neurons therefore play an important role in both the identification of a sensory stimulus and the positive value associated with that sensory experience. The neurons generated shortly after birth are unable to perform this function.
Although most neurons are generated during embryogenesis, some brain regions in mammals are capable of regenerating their neurons in adulthood. The existence of these adult-born neurons has been proven, but many questions about their function and the way in which they integrate into their target areas remain unanswered.
Reward Delivery Anticipation
This research, conducted by the Perception and Memory team (Institut Pasteur/CNRS), directed by Pierre-Marie Lledo, a CNRS Director of Research, has recently revealed the specific role of these neurons produced in the adult brain.
The study demonstrates that assigning positive values to sensory experiences is closely based on the activity of adult-born neurons, and not the neurons formed shortly after birth. It is these new neurons that may enable individuals to anticipate the delivery of a reward.
The team focused on the production of new neurons in adult mice, in particular those neurons that integrate into the olfactory bulb, the brain region responsible for analyzing odors. These new neurons are thought to play a major role in providing flexibility for learning and memorizing olfactory sensory experiences.
The scientists from the Institut Pasteur and the CNRS observed that the new neurons were able to react differently to an odor depending on the consequences associated with that sensory experience, such as whether or not there would be a reward. They also demonstrated that olfactory learning, in which the mice had to associate an odor with positive reinforcement, became easier once the new neurons had been activated.
Finally, simply activating these adult-born neurons could be assimilated with a reward-predicting odor.
To sum up, this research shows that adult-born neurons are involved in the value associated with sensory stimuli rather than just the identification of the nature of a given sensory stimulus. It demonstrates that reward-motivated learning depends largely on adult neurogenesis.
Translated to humans, these findings could improve our understanding of the role played by new neurons in the adult hippocampus in associative learning processes.
The work was supported by Agence Nationale de la Recherche Grants, a Laboratory for Excellence Programme Grant, and the Life Insurance Company AG2R-La Mondiale.
Anne Grelat, Laura Benoit, Sébastien Wagner, Carine Moigneu, Pierre-Marie Lledo, Mariana Alonso
Adult-born neurons boost odor–reward association
Proceedings of the National Academy of Sciences Feb 2018, 201716400; DOI: 10.1073/pnas.1716400115
Image: new neurons in an adult brain. Credit: Mariana Alonso and Pierre-Marie Lledo – Institut Pasteur.