Grey Matter Definition

Grey matter is a major component of the central nervous system, consisting of neuronal cell bodies, neuropil (dendrites and myelinated as well as unmyelinated axons), glial cells (astroglia and oligodendrocytes), synapses, and capillaries. Grey matter is distinguished from white matter, in that it contains numerous cell bodies and relatively few myelinated axons, while white matter contains relatively very few cell bodies and is composed chiefly of long-range myelinated axon tracts.

The color difference arises mainly from the whiteness of myelin. In living tissue, grey matter actually has a very light grey color with yellowish or pinkish hues, which come from capillary blood vessels and neuronal cell bodies.

Structure Of Grey Matter

Grey matter refers to unmyelinated neurons and other cells of the central nervous system1. It is present in the brain, brainstem and cerebellum, and present throughout the spinal cord.

Grey matter is distributed at the surface of the cerebral hemispheres (cerebral cortex) and of the cerebellum (cerebellar cortex), as well as in the depths of the cerebrum (thalamus; hypothalamus; subthalamus, basal gangliaputamen, globus pallidus, nucleus accumbens; septal nuclei), cerebellar (deep cerebellar nuclei – dentate nucleus, globose nucleus, emboliform nucleus, fastigial nucleus), brainstem (substantia nigra, red nucleus, olivary nuclei, cranial nerve nuclei).

Grey matter in the spinal cord is known as the grey column which travels down the spinal cord distributed in three grey columns that are presented in an “H” shape.

The forward-facing column is the anterior grey column, the rear-facing one is the posterior grey column and the interlinking one is the lateral grey column. The grey matter on the left and right side is connected by the gray commissure. The grey matter in the spinal cord consists of interneurons, as well as cell bodies.

Function Of Grey Matter

Grey matter contains most of the brain’s neuronal cell bodies. The grey matter includes regions of the brain involved in muscle control, and sensory perception such as seeing and hearing, memory, emotions, speech, decision-making, and self-control.

The grey matter in the spinal cord is split into three grey columns:

  • The anterior grey column contains motor neurons. These synapse with interneurons and the axons of cells that have travelled down the pyramidal tract. These cells are responsible for the movement of muscles.
  • The posterior grey column contains the points where sensory neurons synapse. These receive sensory information from the body, including fine touch, proprioception, and vibration. This information is sent from receptors of the skin, bones, and joints through sensory neurons whose cell bodies lie in the dorsal root ganglion. This information is then transmitted in axons up the spinal cord in spinal tracts, including the dorsal column-medial lemniscus tract and the spinothalamic tract.
  • The lateral grey column is the third column of the spinal cord.

The grey matter of the spinal cord can be divided into different layers, called Rexed laminae. The above diagram describes, in general, the purpose of the cells within the grey matter of the spinal cord at a particular location.

  1. Kolb & Whishaw Fundamentals of Human Neuropsychology (7th Edition) Worth Publishers ISBN 978-1429282956 ↩︎

Last Updated on November 18, 2023