A High-definition Map Of Liver Cells In Health And Disease

Liver Cells
Researchers have created a high-resolution picture of the cells at work inside a key hub of metabolism — the liver — and shown how disease reprograms individual cell types. In every tissue throughout our bodies, various cell types communicate and coordinate their efforts to perform vital functions and maintain health. The new research not only …

CBD And Genetic Testing Provide Hope For ‘Intractable’ Epilepsy In Children

childhood epilepsy
It can start with a vacant stare, what appear to be muscle twitches or a full-blown seizure. But no matter how it begins, any time a child is diagnosed with epilepsy is often a frightening time for families. About 470,000 children are living with epilepsy in the U.S. While there are over a dozen anti-seizure …

Genome-Wide Association Study Shows Metabolic Origins Of Anorexia

dna sequenceing
Anorexia nervosa is at least partly a metabolic disorder, and not purely psychiatric as previously thought, indicates a global study, led by researchers at King's College London and University of North Carolina at Chapel Hill. The large-scale genome-wide association study, undertaken by over 100 academics worldwide, identified eight genetic variants linked to anorexia nervosa. The …

Psychiatric Disorders Correlation With Prenatal Gene Regulation Confirmed

genetic mutation
Particular genetic variants in the human genome that are important for the development of the brain early in the life of the foetus are frequently found in psychiatric disorders, recent work from Denmark shows. Researchers studied a total of 8 million genetic variants and found that some of them occur particularly often in people who …

Inhibiting USP13 Destroys Alpha-synuclein In Parkinson’s Model

Neurons
USP13 regulates parkin and alpha-synuclein ubiquitination in models of alpha-synucleinopathies, a study from neurologists at Georgetown University Medical Center (GUMC) has found. One defining feature of Parkinson's disease is the clumps of alpha-synuclein protein that accumulate in the brain's motor control area, destroying dopamine producing neurons. Natural processes can't clear these clusters, known as Lewy …

TRP53 Mutatation Impacts DNA Guardian To Promote Cancer Development

Mutant TRP53
A mutant form of the cancer prevention gene p53 'tackles' the normal p53 protein and blocks it from carrying out its protective role, researchers at the Walter and Eliza Hall Institute report. As a result, p53 can no longer activate natural defences against cancer — such as the body's DNA repair process — increasing the …

MiR-137 Gene Potentially Contributes To Neuropsychiatric Disorders

dna
Recent studies of complex brain disorders such as schizophrenia and autism spectrum disorder (ASD) have identified a few "master keys," risk genes that sit at the center of a network of genes important for brain function. Researchers at Emory and the Chinese Academy of Sciences have now created mice partially lacking one of those master …