Functional connectivity magnetic resonance imaging (fcMRI) may predict which high-risk, 6-month old infants will develop autism spectrum disorder by age 2 years, according to a new study.
Siblings of children diagnosed with autism are at higher risk of developing the disorder. Although early diagnosis and intervention can help improve outcomes for children with autism, there currently is no method to diagnose the disease before children show symptoms.
“Previous findings suggest that brain-related changes occur in autism before behavioral symptoms emerge. If future studies confirm these results, detecting brain differences may enable physicians to diagnose and treat autism earlier than they do today,"
said Diana Bianchi, M.D., National Institute of Child Health and Human Development Director.
Functional Brain Connectivity
A research team led by investigators at the University of North Carolina at Chapel Hill and Washington University School of Medicine in St. Louis investigated the brain’s functional connectivity. They focused on regions of the brain work together during different tasks and during rest.
Using fcMRI, the researchers scanned 59 high-risk, 6-month-old infants while they slept naturally. The children were deemed high-risk because they have older siblings with autism. At age 2 years, 11 of the 59 infants in this group were diagnosed with autism.
The researchers used a computer-based technology called machine learning, which trains itself to look for differences that can separate the neuroimaging results into two groups - autism or non-autism - and predict future diagnoses. One analysis predicted each infant’s future diagnosis by using the other 58 infants' data to train the computer program.
Machine Learning Prediction
This method identified 82 percent of the infants who would go on to have autism (9 out of 11), and it correctly identified all of the infants who did not develop autism. In another analysis that tested how well the results could apply to other cases, the computer program predicted diagnoses for groups of 10 infants, at an accuracy rate of 93 percent.
Overall, the team found 974 functional connections in the brains of 6-month-olds that were associated with autism-related behaviors. The authors propose that a single neuroimaging scan may accurately predict autism among high-risk infants, but caution that the findings need to be replicated in a larger group.
“Although the findings are early-stage, the study suggests that in the future, neuroimaging may be a useful tool to diagnose autism or help health care providers evaluate a child’s risk of developing the disorder,"
said Joshua Gordon, M.D., Ph.D., National Institute of Mental Health Director. The work was funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the National Institute of Mental Health.
Emerson RW, Adams C, Nishino T, Hazlett HC, Wolff JJ, Zwaigenbaum L, Constantino JN, Shen MD, Swanson MR, Elison JT, Kandala S, Estes AM, Botteron KN, Collins L, Dager SR, Evans AC, Gerig G, Gu H, McKinstry RC, Paterson S, Schultz RT, Styner M, the IBIS Network, Schlaggar BL, Pruett, Jr. JR, and Piven J Functional neuroimaging in high-risk 6-month-old infants predicts later autism Science Translational Medicine, 2017 DOI: 10.1126/scitranslmed.aag2882
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