A blood-clotting protein called fibrinogen is responsible for a series of molecular and cellular events that can destroy connections between neurons in the brain and result in cognitive decline, new research shows. Scientists at the Gladstone Institutes, led by Senior Investigator Katerina Akassoglou, Ph.D., used state-of-the-art imaging technology to study both mouse brains and human… Read more

Patients with Sjögren syndrome have a significant increase in a specific immune cell type called T follicular regulatory cells (Tfr), a team from Instituto de Medicina Molecular Lisboa has found. These cells are usually found in lymphoid tissues, where they regulate antibody production. It was a surprise to find an increase of this type of… Read more

The mechanism that C10, a human antibody previously identified to react with the Dengue virus, uses to prevent Zika infection at a cellular level, has been identified by a team of researchers at Duke-NUS Medical School (Duke-NUS), in collaboration with scientists from the University of North Carolina. C10 was previously identified as one of the… Read more

A cell surface molecule known as CD98 promotes acute myeloid leukemia, researchers at University of California San Diego School of Medicine and Moores Cancer Center have discovered. They have also found that inhibiting CD98 with the therapeutic antibody IGN523 blocks acute myeloid leukemia growth in patient-derived cells and mouse models. Acute myeloid leukemia (AML) is… Read more

Proteins known as broadly neutralizing antibodies (bNAbs) are a promising key to the prevention of infection by HIV, the virus that causes AIDS. bNAbs have been found in blood samples from some HIV patients whose immune systems can naturally control the infection. These antibodies may protect a patient’s healthy cells by recognizing a protein called… Read more