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Fibrinogen Promotes Synapse Loss In Alzheimer’s Disease Model

A blood-clotting protein called fibrinogen is responsible for a series of molecular and cellular events that can destroy connections between neurons in the brain and result in cognitive decline, new research shows. Scientists at the Gladstone Institutes, led by Senior Investigator Katerina Akassoglou, Ph.D., used state-of-the-art imaging technology to study both mouse brains and human […]

How C10 Antibodies Neutralize Zika Infection

The mechanism that C10, a human antibody previously identified to react with the Dengue virus, uses to prevent Zika infection at a cellular level, has been identified by a team of researchers at Duke-NUS Medical School (Duke-NUS), in collaboration with scientists from the University of North Carolina. C10 was previously identified as one of the […]

Therapeutic Antibody Blocks Acute Myeloid Leukemia Growth

A cell surface molecule known as CD98 promotes acute myeloid leukemia, researchers at University of California San Diego School of Medicine and Moores Cancer Center have discovered. They have also found that inhibiting CD98 with the therapeutic antibody IGN523 blocks acute myeloid leukemia growth in patient-derived cells and mouse models. Acute myeloid leukemia (AML) is […]

An Antibody That Can Attack HIV In New Ways

Proteins known as broadly neutralizing antibodies (bNAbs) are a promising key to the prevention of infection by HIV, the virus that causes AIDS. bNAbs have been found in blood samples from some HIV patients whose immune systems can naturally control the infection. These antibodies may protect a patient’s healthy cells by recognizing a protein called […]