Microglial TREM2 Has Protective Role In Amyotrophic Lateral Sclerosis

Microglia play a protective role in a mouse model of amyotrophic lateral sclerosis (ALS), according to new preclinical studies from Mayo Clinic scientists and collaborators1. The finding could provide a potential therapeutic target for the disease. The loss of neurons characterizes the neurodegenerative diseases of Alzheimer’s and ALS. In Alzheimer’s, the lost neurons handle memory…

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Amyotrophic Lateral Sclerosis: Marking The Differences In Motoneurons

The world’s attention was focused on amyotrophic lateral sclerosis (ALS) recently with the death of Stephen Hawking. The famous physicist had a rare form of slowly progressing ALS that resulted in a gradual loss of motor function. Perhaps the experience of the disease is best conveyed by Hawking himself: “I have lived with the prospect…

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