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Tag: Amyotrophic lateral sclerosis

Why A Toxin Produced By Saltwater Algae May Lead To ALS

A computer generated-simulation has allowed scientists to see how a toxin produced by algal blooms in saltwater might cause Amyotrophic Lateral Sclerosis (ALS). Penn State College of Medicine researchers investigated an environmental toxin called β-Methylamino-L-alanine (BMAA) that has been linked[1] to significantly increased occurrence of sporadic amyotrophic lateral sclerosis in populations with frequent dietary consumption […]

ALS Trajectory May Be Affected By Gut Microbes

Intestinal microbes, collectively termed the gut microbiome, may affect the course of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, researchers at the Weizmann Institute of Science have shown in mice. Progression of an ALS-like disease was slowed after the mice received certain strains of gut microbes or substances known to be secreted […]

Pericytes Secrete A Substance In The Brain That Protects Neurons

A new study helps explain the cascade of problems that lead to neurodegeneration after stroke or traumatic brain injury, as well as in diseases like Alzheimer’s and Parkinson’s. It also suggests a potential strategy for therapy. “What this paper shows is if you lose these vascular cells, you start losing neurons. The link with neurodegeneration […]

STMN2 Gene A Potential Therapeutic Target For ALS

A potential new biomarker and drug target for amyotrophic lateral sclerosis has been identified by research led by stem cell scientists at Harvard University. The study used stem cell models of human motor neurons to reveal the gene STMN2 as a potential therapeutic target, demonstrating the value of this human stem cell model approach in […]

Potential Drug Target Found For Spinocerebellar Ataxia Type 2

A protein, called Staufen1, accumulates in cells of patients suffering from degenerative ataxia or amyotrophic lateral sclerosis (ALS), scientists at University of Utah Health report for the first time. Depleting the protein from affected mice improved symptoms including motor function. These results suggest that targeting Staufen1 could have therapeutic potential in people. “This is a […]