Overnight amygdala adaptation fails proportionally to the restlessness of REM sleep, new research from the Netherlands Institute for Neuroscience suggests. The finding helps explain why you will be better able to bear tomorrow what you are distressed about today, and why that can go wrong.
Something frightening or unpleasant does not go unnoticed. In our brain, the so-called limbic circuit of cells and connections immediately becomes active.
First and foremost, such experiences activate the amygdala. This nucleus of brain cells located deep in the brain can be regarded as the siren of the brain, signalling attention!
In order for the brain to function properly, the siren must also be switched off again. For this, a restful REM sleep, the part of the sleep with the most vivid dreams, turns out to be essential.
The researchers placed their participants in a MRI scanner in the evening and presented a specific odor while they made them feel upset. The brain scans showed how the amygdala became active.
The participants then spent the night in the sleep lab, while the activity of their sleeping brain was measured with EEG, and the specific odor was presented again on occasion. The next morning, the researchers tried to upset their volunteers again, in exactly the same way as the night before.
But now they did not succeed so well in doing this.
Brain circuits had adapted overnight; the siren of the brain no longer went off. The amygdala responded much less, especially in those who had had a lot of restful REM sleep and where meanwhile exposed to the specific odor.
But among the participants were also people with restless REM sleep. Things went surprisingly different for them.
Brain circuits had not adapted well overnight: the siren of the brain continued to sound the next morning. And while the nocturnal exposure to the odor helped people with restful REM sleep adapt, the same exposure only made things worse for people with restless REM sleep.
During sleep, ‘memory traces’ of experiences from the past day are spontaneously played back, like a movie.
“Among all remnants of the day, a specific memory trace can be activated by presenting the same odor as the one that was present during the experience while awake. Meanwhile, memory traces are adjusted during sleep: some connections between brain cells are strengthened, others are weakened. Restless REM sleep disturbs these nocturnal adjustments, which are essential for recovery and adaptation to distress,”
says Rick Wassing, first author of the study.
Could Transdiagnostically Help
The finding can be of great importance for about two-thirds of all people with a mental disorder, as both restless REM sleep and a hyperactive amygdala are the hallmarks of post-traumatic stress disorder (PTSD), anxiety disorders, depression and insomnia.
People with PTSD carry their traumatic experience to the next day: people with an anxiety disorder take their greatest fear with them, people with depression their despair, and people with chronic insomnia their tension. Authors Rick Wassing, Frans Schalkwijk and Eus van Someren predict that treatment of restless REM sleep could transdiagnostically help to process emotional memories overnight and give them a better place in the brain.
The work was supported by a ZONMW Neuropsychoanalysis Fund grant from the Netherlands Organization of Scientific Research (NWO), by a grant from the Bial Foundation, and by the European Research Council grants.
Rick Wassing, Oti Lakbila-Kamal, Jennifer R. Ramautar, Diederick Stoffers, Frans Schalkwijk, Eus J.W. Van Someren Restless REM Sleep Impedes Overnight Amygdala Adaptation Current Biology; July 11, 2019, DOI:https://doi.org/10.1016/j.cub.2019.06.034