A new neuroimaging study investigates how psychotherapy for people with PTSD changes the brain areas responsible for generating emotional responses to threats used.

Trauma-focused psychotherapy is considered the best available treatment for post-traumatic stress disorder (PTSD). However, the ways in which this method affects the brain to promote recovery from PTSD are not well understood.

We know that psychotherapy works. But we don’t have a lot of good data to explain how it works, how the brain is changed by going through this process. That’s what we sought to find out,

says Greg Fonzo, an assistant professor in the psychiatry and behavioral sciences department at Dell Medical School at the University of Texas at Austin, and lead author of the study1.

Trauma-focused Psychotherapy

Post-traumatic stress disorder may occur in people who have experienced or witnessed a traumatic event. Symptoms can include flashbacks, nightmares, and severe anxiety, as well as uncontrollable thoughts about the event.

Trauma-focused psychotherapy is a treatment that helps people recover from a traumatic event, using techniques such as in vivo exposure, which involves directly facing a feared object, situation, or activity in real life, and imaginal exposure, which involves facing the trauma memory. A person who is afraid of crowds, for example, may be repeatedly exposed to large gatherings.

At first, that patient will obviously experience fear or whatever negative emotion is triggered by being in a crowd. But it’s like looking at a fire from behind a window. It appears to be a dangerous situation, but the person is actually quite safe. After a while, the fire will burn out, and the person recognizes there was no actual danger. And so that process eventually promotes new learning in the brain,

says Fonzo.

Amygdala And Insula

Fonzo and his colleagues used functional magnetic resonance imaging (fMRI) scans to identify how brain networks communicate with one another before and after treatment. Specifically, they measured the degree of communication or “traffic,” known as functional connectivity, between the amygdala and insula, areas of the brain responsible for emotion, logic and thinking.

What we discovered was a reduction in traffic between these brain regions among patients who had undergone trauma-focused psychotherapy. In fact, greater connectivity changes were associated with bigger symptom reductions. This restructuring of brain communication may be a unique signature of PTSD recovery,

says Fonzo.

The findings could change the way doctors treat people who suffer from PTSD.

Now that we have a better understanding of the brain mechanisms underlying psychotherapy, we may be able to use this information to develop new and better treatments for people with PTSD,

he adds.


  1. G. Fonzo, et al. Amygdala and Insula Connectivity Changes Following Psychotherapy for Posttraumatic Stress Disorder: A Randomized Clinical Trial. Biological Psychiatry. DOI: https://doi.org/10.1016/j.biopsych.2020.11.021 ↩︎


For future updates, subscribe via Newsletter here or Twitter