Pain is not just a matter of nerves. Non-neuronal cells, the glial cells, are also involved in clinically relevant pain models, and their activation is sufficient to amplify pain, researchers at MedUni Vienna’s Center for Brain Research have discovered.
The sensation of pain occurs when neural pathways conduct excitation generated by tissue damage to the spinal cord, where the nociceptive information is extensively pre-processed. From there, the information is transmitted to the human brain, where the sensation of “pain” is finally created. This has been the general belief.
Glial cells are the commonest type of cells in the human brain and spinal cord. They surround neurons but are distinct from them and play an important supporting role – for example, in material transport and metabolism or the fluid balance in the brain and spinal cord.
Glial Cells Activation Pain Phenomena
However, when glial cells are activated, by pain processes, for example, glial cells are themselves able to release messenger substances, such as inflammatory cytokines.
Glial cells therefore have two modes: a protective and a pro-inflammatory mode.
“The activation of glial cells results in a pain-amplifying effect, as well as spreading the pain to previously unaffected parts of the body. For the very first time, our study provides a biological explanation for this and for other hitherto unexplained pain phenomena in medicine,”
says Jürgen Sandkühler, Head of the Division of Neurophysiology at MedUni Vienna’s Center for Brain Research.
Over-activation of glial cells in the spinal cord can, for example, be caused by strong pain stimuli from a wound or surgical intervention, or even by opiates. Says Sandkühler:
“This could also explain why opiates are initially very good at relieving pain but then often cease to be effective. Another example is the phenomenon of “withdrawal” in drug addicts, where activated glial cells cause severe pain throughout the body.”
According to Sandkühler, neuroinflammatory diseases of the brain, environmental factors and even the person’s own lifestyle can lead to activation of glial cells. Examples from the current literature are: depression, anxiety disorders and chronic stress, multiple sclerosis or Alzheimer’s and diabetes, as well as lack of exercise and poor diet.
“Glial cells are an important factor in ensuring the equilibrium of a person’s neuroinflammatory system.”
The study results give grounds for speculation that improvements in a person’s lifestyle could have a beneficial impact upon this system and ensure that they generally suffer less pain or “minor niggles”, says Sandkühler:
“It is therefore in our own hands: thirty minutes of moderate exercise three or four times a week, a healthy diet and avoiding putting on excess weight can make a huge difference.”
M. T. Kronschläger, R. Drdla-Schutting, M. Gassner, S. D. Honsek, H. L. Teuchmann, J. Sandkühler
Gliogenic LTP spreads widely in nociceptive pathways
Science 10 Nov 2016: DOI: 10.1126/science.aah5715
Image: MRC NIMR, Wellcome Images