Gene Expression Rhythms Are Disrupted In Schizophrenia-Affected Brains

mitosis
Rhythms in gene expression in the brain are highly disrupted in people with schizophrenia, according to a new University of Pittsburgh-led study. The findings also suggest that researchers studying schizophrenia-linked genes in the brain could have missed important clues that would help understand the disease. "Our study shows for the first time that there are …

Brain Network Structures Can Change Over Time

spatial chronnectome
The connectivity and shape of brain networks — discrete areas of the brain that work together to perform complex cognitive tasks — can alter in fundamental and recurring ways over time, a study led by Georgia State University suggests. The researchers gathered functional magnetic resonance imaging (fMRI) brain imaging data to develop pictures of network …

Broccoli Sprout Compound May Restore Brain Chemistry Imbalance Linked To Schizophrenia

broccoli
A set of chemical imbalances in the brains of people with schizophrenia related to the chemical glutamate has been elucidated by Johns Hopkins Medicine researchers in recently published studies using animals and people. They have also dicovered how to regulate the levels using a compound derived from broccoli sprouts. The results advance the hope that …

Schizophrenia: Adjunctive Antidepressant Treatment Reduced Risk Of Psychiatric Hospitalization

Jon Olav Eikenes
Certain combinations of psychiatric medication may be more effective than others in treating patients with schizophrenia, a new study suggests. Combining medications is often referred to as polypharmacy. Antipsychotic drugs are usually the first line of treatment for individuals with schizophrenia. But because these drugs often fail to control symptoms adequately on their own, doctors …

Abnormal Epstein-Barr Virus Response May Contribute To Schizophrenia

Epstein-Barr virus
People with schizophrenia also have higher levels of antibodies against the Epstein-Barr virus according to new research from Johns Hopkins Medicine and Sheppard Pratt Health System. Epstein-Barr virus (EBV), is a herpes virus that causes infectious mononucleosis, so-called mono. Researchers proposed two explanations for the association of heightened immune responses in patients with schizophrenia and …

Gene Expression Regulating Enzyme Dysregulated In Schizophrenia

Martinostat
Epigenetic differences between the brains of individuals with schizophrenia and those of unaffected study participants have been identified in a study using a PET scan tracer developed at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital (MGH). The study details differences in the expression of histone deacetylase (HDAC) enzymes, important regulators of gene …

Neonatal Vitamin D Deficiency Link To Schizophrenia Confirmed

Hippocampal bone morphogenetic protein
Newborns with vitamin D deficiency have an increased risk of schizophrenia later in life, a team of Australian and Danish researchers has reported. The finding may help prevent some cases of the disease by treating vitamin D deficiency during the earliest stages of life. The study, led by Professor John McGrath from The University of …

Oligodendrocyte Abnormalities In Schizophrenia Confirmed

in vitro oligodendrocytes
Using cultured cells from patients with psychotic disorders, such as schizophrenia, to investigate abnormalities in nerve connections in the brain could lead to new treatments, a recent study shows. Strong correlations were observed between the findings in the cells in culture — grown outside the body in a controlled environment — and findings from brain …