Genome editing has been used to demonstrate the efficacy of CRISPR-Cas to treat the genetic problem that causes cystic fibrosis. The approach adopted by the research team opens new perspectives in the treatment of the genetic disease for which no cure is currently available. The disease is caused by a mutation of the gene that… Read more

A new RNA editing technique, named RESCUE (RNA Editing for Specific C to U Exchange), has been developed by investigators at MIT’s McGovern Institute for Brain Research. The team, led by core member Feng Zhang, and including first co-authors Omar Abudayyeh and Jonathan Gootenberg (both now McGovern Fellows), made use of a deactivated Cas13 to… Read more

For the first time, scientists have eliminated replication-competent HIV-1 DNA – the virus responsible for AIDS – from the genomes of living animals. The study, a joint effort from researchers at the Lewis Katz School of Medicine at Temple University and the University of Nebraska Medical Center (UNMC), marks a critical step toward the development… Read more

A team that includes the scientist who first harnessed the revolutionary CRISPR-Cas9 and other systems for genome editing of eukaryotic organisms, including animals and plants, has engineered another CRISPR system, called Cas12b. The new system offers improved capabilities and options when compared to CRISPR-Cas9 systems. In a study published in Nature Communications, Feng Zhang and… Read more

A new technology for simultaneously analyzing the functions of hundreds of genes with resolution reaching the single cell level has been developed by scientists at Mount Sinai Hospital. The method relies on a barcoding approach using a novel protein. Since the sequencing of the first human genome in the early 2000s revealed a set of… Read more