A drug originally developed to treat neurological diseases, called URMC-099, protected mice from non-alcoholic fatty liver disease, which is caused by a high-fat diet, a new study reports.
Researchers designed the diet they fed the mice to replicate the Western fast food diet and recreate the features of non-alcoholic fatty liver disease found in people. The drug was well tolerated and the research team plans further testing in order to move URMC-099 into early phase human clinical trials.
Obesity often leads to non-alcoholic fatty liver disease, and estimates suggest that 64 million people have the disorder in the United States alone. Individuals with the most severe form of the disease, called non-alcoholic steatohepatitis (NASH), have inflammation and liver cell damage, which can lead to scarring, cirrhosis, and liver cancer.
Other than weight loss, there are no treatment options.
Eating lots of fatty and sugary foods triggers inflammation in the liver and the body responds by sending immune cells to neutralize the threat. Unfortunately, the immune response can rage out of control, creating even more inflammation and further damaging the liver.
URMC-099, which was discovered in the laboratory of scientist Harris A. (Handy) Gelbard, dials back the immune response to a normal level.
“URMC-099 seems to break this vicious cycle of persistent inflammation by restoring balance between immune cells and liver cells. The drug’s ability to turn down the volume on the immune response allows the liver to regain its normal functions,”
says Gelbard, professor and director of the Center for Neurotherapeutics Discovery at the University of Rochester Medical Center.
URMC-099 And Obesity
A new therapy for non-alcoholic fatty liver disease is needed now more than ever: according to the Centers for Disease Control and Prevention, more than a third of adults in the US are obese and that number is expected to climb.
Gelbard, working with scientists at the Mayo Clinic and University of Cincinnati, fed mice the high fat, sugar, and cholesterol diet for six weeks. After five-and-a-half weeks on the diet, half of the mice received URMC-099 and half received placebo.
The mice given the drug had less immune-related inflammation and less liver injury and fibrosis compared to placebo-treated mice and didn’t experience any major side effects.
Gelbard, who originally developed URMC-099 to treat neurological disorders, is working to pursue different opportunities to develop URMC-099 for clinical trials for non-alcoholic fatty liver disease.
Kyoko Tomita … Burns C. Blaxall, Samar H. Ibrahim Mixed-lineage kinase 3 pharmacological inhibition attenuates murine nonalcoholic steatohepatitis JCI Insight. 2017;2(15):e94488. doi:10.1172/jci.insight.94488
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