Adding risperidone to parent training and a stimulant also improves teachers’ assessments of anxiety and social avoidance, new research shows.

Earlier research from The Ohio State University Wexner Medical Center and three other institutions showed that when children with attention-deficit/hyperactivity disorder (ADHD) and serious physical aggression were prescribed both a stimulant and an antipsychotic drug, along with teaching parents behavior management techniques, they had a reduction of aggressive and serious disruptive behavior.

Now, L. Eugene Arnold and Michael Aman, professors emeritus at the Nisonger Center at Ohio State’s Wexner Medical Center, and their colleagues have published a study, available online in the Journal of Child and Adolescent Psychopharmacology, showing the addition of risperidone to parent training and a stimulant also improves teachers’ assessments of anxiety and social avoidance. Improvement in teacher-rated anxiety and social withdrawal also contributed to improvements in parent-rated disruptive behavior.

Children who showed reduced anxiety also showed less disruptive behavior.

Disruptive Behavior and Attention-deficit Disorders

In the project, “Treatment of Severe Childhood Aggression (TOSCA) Study,” 168 children, ages 6-12, who had been diagnosed with ADHD and disruptive behavior disorder (DBD) and displayed severe physical aggression were randomly assigned to two groups: parent training plus stimulant plus placebo (Basic treatment) or parent training plus stimulant plus the antipsychotic drug risperidone (Augmented treatment). All participants received only parent training plus stimulant for the first three weeks of the nine-week study.

Commented Aman, also coordinating principal investigator of the multi-site study:

“We wanted to see if we could expand or augment treatment by adding a second medication. So, we added a placebo for the ‘Basic group’ and added risperidone for the ‘Augmented group,’ if there was room for improvement at the end of the third week."

Teacher ratings showed a significant advantage for the “Augmented group” receiving the stimulant drug plus risperidone and parent training, compared to the “Basic group,” for symptoms of anxiety.

“Clinicians need to attend to both internal emotional and external behavioral symptoms in children presenting with aggressive symptoms. Aggression accompanied by anxiety and social avoidance may partially reflect an anxiety-driven fight-or-flight reaction, which we speculate may respond to specific anxiety treatment,” Arnold said. “This possibility deserves further exploration."


Michael G. Aman. Treatment of Severe Childhood Aggression (TOSCA) Studies. JCAP, 2015; 25 (3): 201 DOI: 10.1089/cap.2015.2532

Photo: Magdalena Roeseler/flickr

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