What if we were able to modify the negative effect of a returning memory that elicits fear? A research group from the University of Bologna succeeded was able to do this and has developed a new non-invasive experimental protocol.

The result of this study, published in the journal Current Biology, is an innovative method that combines fear conditioning - a stimulus associated with something unpleasant, that induces a negative memory - and the neurostimulation of a specific site of the prefrontal cortex.

The process alters the perception of an unpleasant (aversive) event so that it will no longer induce fear.

“This experimental protocol combining transcranial stimulation and memory reconsolidation allowed us to modify an aversive memory that the participants had learned the day before. This result has relevant repercussions for understanding how memory works. It might even lead to the development of new therapies to deal with traumatic memories,"

explains first author Sara Borgomaneri of the University of Bologna.

Memory Reconsolidation

The primary focus of the research group is the process of reconsolidation. This process maintains, strengthens, and alters those events that are already stored in our long-term memory.

“Every time an event is recalled in our memory, there is a limited period of time in which it can be altered. The protocol we developed exploits this short time window and can, therefore, interfere with the reconsolidation process of learned aversive memories,"

says Simone Battaglia, researcher and co-author of this study.

Erasing Aversive Memories

The researchers used Transcranial Magnetic Stimulation (TMS) to “erase” the fear induced by a negative memory. With an electromagnetic coil placed on the head of the participant, TMS creates magnetic fields that can alter the neural activity of specific brain areas.

TMS is a non-invasive procedure that does not require surgery or any action on the participant and for this reason is widespread in research as well as in clinic and rehabilitation programmes.

“With TMS, we could alter the functioning of the prefrontal cortex, which proved to be fundamental in the reconsolidation process of aversive memories. Thanks to this procedure, we obtained results that, until now, were only possible by delivering drugs to patients,"

says Sara Borgomaneri.

The Study

The research group developed this protocol through a trial involving 98 healthy people. Every participant had learned an aversive memory and the next day underwent a TMS session over the prefrontal cortex.

“First, we created the aversive memory by combining an unpleasant stimulation with some images”, explains Borgomaneri. “The day after, we presented a group of participants with the same stimulus, which, in their memory, was recorded as aversive. Using TMS immediately afterwards, we interfered with their prefrontal cortex activity”.

To test the effectiveness of the protocol, other groups of participants underwent TMS without their aversive memory to be recalled (no reconsolidation was triggered), and some other groups were stimulated with TMS in control brain areas, not involved in memory reconsolidation.

At that point, the only thing left to do for researchers was to evaluate the effectiveness of TMS. They waited for another day and once again tested how the participants reacted when the aversive memory was recalled.

They obtained encouraging results.

Participants who had their prefrontal cortex activity inhibited by TMS showed a reduced psycho-physiological response to the unpleasant stimulus. They remembered the event (explicit memory) but its negative effect was substantially reduced.

“This trial showed that it is feasible to alter the persistence of potentially traumatic memories. This may have crucial repercussions in the fields of rehabilitation and clinical medicine. We’re dealing with a new technique that can be employed in different contexts and can assume a variety of functions, starting from treating PTSD, which will be the focus of our next study,"

says Professor Giuseppe di Pellegrino, who coordinated the study.


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