Alzheimer’s disease has a complex and faceted set of disease mechanisms. Although it is typically defined as a disease which affects the neurons of the brain, it has become increasingly apparent that the disease also affects the vasculature of the brain in Alzheimer’s progression. The ‘dual hit’ hypothesis suggests that damage to the brains vasculature…
Tag: vascular biology
Albuminuria Increases Alzheimer’s Disease & Vascular Dementia Risk
Alzheimer’s disease and vascular dementia both are, respectively, the first and second most common neurodegenerative diseases. Although dementia is a massive global issue, the actual mechanisms causing these diseases are relatively unknown with multiple diseases increasing the risk of developing a dementia. A recent study has established a link between albuminuria and both Alzheimer’s disease…
Neural and Vascular Interactions Regulate Brain Blood Vessel Growth
Blood flow – and the vasculature which enables this – is of critical importance to most tissues and organs of the body. The health and stability of vasculature in the brain are particularly crucial to general health and cognition, with the brain consuming 20% of cardiac output despite only making up 2% of the body’s…
Eye Imaging Provides Neurovascular Biomarker In Alzheimer’s Subjects
The relationship between blood flow in the brain and neurodegenerative diseases is well documented and gaining prominence in research circles. The dysfunction of brain blood flow (neurovascular dysfunction) has been shown to disrupt the removal of the key Alzheimer’s protein amyloid-beta as well as damaging brain cells from leakage of foreign cells into the brain…
Alzheimer's Disease May Be Triggered By Vascular System Alterations
A plasma component normally involved in blood clotting and inflammation may play a role in the development of Alzheimer’s disease in some patients, scientists at Rockefeller University report. This is not the first time the condition has been linked to the vascular system. Yet it’s still not clear precisely how changes in the blood might…
Blood-brain Barrier Leakage Linked To Alzheimer’s Disease
In a new study using contrast-enhanced MRI, researchers have identified leakages in the blood-brain barrier (BBB) of people with early Alzheimer’s disease (AD). The findings suggest increased BBB permeability may be a key mechanism in the early stages of the disease. Researchers used contrast-enhanced MRI to compare 16 early AD patients with 17 healthy age-matched…