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Unique Tau Filament Structures Found In Chronic Traumatic Encephalopathy

The atomic structures of the abnormal tau filaments associated with chronic traumatic encephalopathy (CTE), a head injury-associated neurodegenerative disease, are investigated in new research from the MRC Laboratory of Molecular Biology (LMB). The work found that the filaments differ in structure from those seen in Alzheimer’s disease. The findings could lead to improved diagnosis of […]

Fibrinogen Promotes Synapse Loss In Alzheimer’s Disease Model

A blood-clotting protein called fibrinogen is responsible for a series of molecular and cellular events that can destroy connections between neurons in the brain and result in cognitive decline, new research shows. Scientists at the Gladstone Institutes, led by Senior Investigator Katerina Akassoglou, Ph.D., used state-of-the-art imaging technology to study both mouse brains and human […]

Cell Study Reveals How Head Injuries Lead To Serious Brain Diseases

How head injuries adversely affect individual cells and genes that can lead to serious brain disorders is detailed in a new study from biologists at UCLA. The scientists provide the first cell “atlas” of the hippocampus when it is affected by traumatic brain injury. The team also proposes gene candidates for treating brain diseases associated […]

Traumatic Brain Injury Can Induce Abnormal Tau Protein Deposits

The first evidence has been published that a single traumatic brain injury can generate an abnormal form of the dementia associated protein tau, which can slowly spread through the brain, resulting in memory deficits and neuronal damage. The landmark study comes from the Mario Negri Institute for Pharmacological Research of Milan and the University of […]