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Tag: telomerase

Two Enzymes Synergize To Modulate Activity Of Telomerase

New research identifies cellular processes that appear to supercharge both growth and shrinkage of telomeres — the chemical “caps” on chromosomes associated with aging. The work, which focused on two enzymes in yeast, could lead to new insights on stopping runaway cellular growth in cancer tumors and the treatment of premature aging disorders such as […]

TERT Promoter Mutation Is Key To Glioblastoma’s ‘Immortality’

Patient-derived glioblastoma cells with telomerase reverse transcriptase (TERT) promoter mutations depend on a particular form of a protein called GABP for their survival, UC San Francisco researchers have discovered. The finding reveals how a mutation in the gene regulator – the third most common mutation among all human cancers and the most common mutation in […]