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Alzheimer’s Disease As A Double-Prion Disorder

Two proteins involved in Alzheimer’s disease pathology act as prions — misshapen proteins that spread through tissue like an infection by forcing normal proteins to adopt the same misfolded shape — new research from UC San Francisco indicates. Using novel laboratory tests, the researchers were able to detect and measure specific, self-propagating prion forms of […]

Unique Tau Filament Structures Found In Chronic Traumatic Encephalopathy

The atomic structures of the abnormal tau filaments associated with chronic traumatic encephalopathy (CTE), a head injury-associated neurodegenerative disease, are investigated in new research from the MRC Laboratory of Molecular Biology (LMB). The work found that the filaments differ in structure from those seen in Alzheimer’s disease. The findings could lead to improved diagnosis of […]

Neuroscientists Identify Gene Networks Tied To Dementia

A UCLA-led research team has pinpointed genetic processes involved in the neurodegeneration that occurs in dementia. This represents an important step on the path toward developing therapies that could slow or halt the course of the disease. The researchers discovered two major groups of genes involved in mutations that result in an overproduction of a […]

Alzheimer’s-associated Tau Disrupts Nucleocytoplasmic Transport

How tau interferes with communication between the nucleus of neurons and the rest of the cell body, called the cytoplasm, is elucidated in a new study led by investigators at Massachusetts General Hospital (MGH) and Johns Hopkins School of Medicine. The abnormal form of tau that accumulates in the neurofibrillary tangles that characterize Alzheimer’s disease […]