tau

Certain molecules involved in Alzheimer’s disease called tau-proteins spread more easily in the aging brain, new research in mice from German investigators suggests. The study was carried out in collaboration with researchers in the US at Harvard Medical School and Massachusetts General Hospital. Alzheimer’s disease usually begins with memory decline and later affects other cognitive… Read more

Several years ago, MIT neuroscientists showed that they could dramatically reduce the amyloid plaques seen in mice with Alzheimer’s disease simply by exposing the animals to light flickering at a specific frequency. In a new study, the researchers have found that this treatment has widespread effects at the cellular level, and it helps not just… Read more

Two proteins involved in Alzheimer’s disease pathology act as prions — misshapen proteins that spread through tissue like an infection by forcing normal proteins to adopt the same misfolded shape — new research from UC San Francisco indicates. Using novel laboratory tests, the researchers were able to detect and measure specific, self-propagating prion forms of… Read more

The atomic structures of the abnormal tau filaments associated with chronic traumatic encephalopathy (CTE), a head injury-associated neurodegenerative disease, are investigated in new research from the MRC Laboratory of Molecular Biology (LMB). The work found that the filaments differ in structure from those seen in Alzheimer’s disease. The findings could lead to improved diagnosis of… Read more

Sleep deprivation increases levels of the key Alzheimer’s protein tau, researchers at Washington University School of Medicine in St. Louis have found. The findings indicate that lack of sleep alone helps drive the disease, and suggests that good sleep habits may help preserve brain health. “The interesting thing about this study is that it suggests… Read more