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Tau-mediated RNA Splicing Errors Linked To Alzheimer’s Disease

A novel mechanistic link between alterations in RNA splicing and tau-mediated neurodegeneration in Alzheimer’s disease us reported in a collaborative study in the journal Cell Reports[1]. The study, led by researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, integrates data from human brain autopsy […]

Alzheimer’s Disease Destroys Neurons That Keep Us Awake

Researchers and caregivers have noted that excessive daytime napping can develop long before the memory problems associated with Alzheimer’s disease begin to unfold. Prior studies have considered this excessive daytime napping to be compensation for poor nighttime sleep caused by Alzheimer’s-related disruptions in sleep-promoting brain regions, while others have argued that the sleep problems themselves […]

Super-resolution Microscopy Sheds Light On How Dementia Protein Becomes Dysfunctional

Super-resolution microscopy was used by University of Queensland researchers to observe key molecules at work inside living brain cells, further unravelling the puzzle of memory formation and the elusive causes of dementia. “One of the distinguishing features of Alzheimer’s disease is the tangles of Tau protein that form inside brain cells, but this is the […]

Tau Proteins Spread More Easily In The Aging Brain

Certain molecules involved in Alzheimer’s disease called tau-proteins spread more easily in the aging brain, new research in mice from German investigators suggests. The study was carried out in collaboration with researchers in the US at Harvard Medical School and Massachusetts General Hospital. Alzheimer’s disease usually begins with memory decline and later affects other cognitive […]