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Alzheimer’s Disease Destroys Neurons That Keep Us Awake

Researchers and caregivers have noted that excessive daytime napping can develop long before the memory problems associated with Alzheimer’s disease begin to unfold. Prior studies have considered this excessive daytime napping to be compensation for poor nighttime sleep caused by Alzheimer’s-related disruptions in sleep-promoting brain regions, while others have argued that the sleep problems themselves […]

Super-resolution Microscopy Sheds Light On How Dementia Protein Becomes Dysfunctional

Super-resolution microscopy was used by University of Queensland researchers to observe key molecules at work inside living brain cells, further unravelling the puzzle of memory formation and the elusive causes of dementia. “One of the distinguishing features of Alzheimer’s disease is the tangles of Tau protein that form inside brain cells, but this is the […]

Tau Proteins Spread More Easily In The Aging Brain

Certain molecules involved in Alzheimer’s disease called tau-proteins spread more easily in the aging brain, new research in mice from German investigators suggests. The study was carried out in collaboration with researchers in the US at Harvard Medical School and Massachusetts General Hospital. Alzheimer’s disease usually begins with memory decline and later affects other cognitive […]

Alzheimer’s Disease As A Double-Prion Disorder

Two proteins involved in Alzheimer’s disease pathology act as prions — misshapen proteins that spread through tissue like an infection by forcing normal proteins to adopt the same misfolded shape — new research from UC San Francisco indicates. Using novel laboratory tests, the researchers were able to detect and measure specific, self-propagating prion forms of […]