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Serotonin Levels May Clarify Unexplained Pain

A newly-discovered biological mechanism could explain heightened somatic awareness, in which people experience pain that has no physiological explanation. Patients with heightened somatic awareness often experience unexplained symptoms — headaches, sore joints, nausea, constipation, or itchy skin — that cause emotional distress, and are twice as likely to develop chronic pain. The condition, associated with […]

Serotonin Regulates Neuronal Mitochondria Biogenesis

A role for the mitochondrial effects of the neurotransmitter serotonin in the facilitation of stress adaptation has been identified in new research. Mitochondria in neurons are the powerhouses that generate energy to execute cellular functions and regulate neuronal survival under conditions of stress. The collaborative research, conducted by Prof. Vidita Vaidya and Prof. Ullas Kolthur-Seetharam […]

Serotonergic Circuitry Differs In SSRI Resistant Major Depressive Disorder Patients

Differences in growth patterns of neurons of SSRI-resistant patients have been discovered by researchers at Salk Institute. The work has implications for depression as well as other psychiatric conditions such as bipolar disorder and schizophrenia that likely also involve abnormalities of the serotonin system in the brain. Selective serotonin reuptake inhibitors (SSRIs) are the most […]

Serotonin Can Regulate Gene Expression Inside Neurons

The neurotransmitter serotonin, known for its role in passing signals between neurons in the brain, is also able to regulate expression of genes within neurons in an unexpected way, according to new research conducted by neuroscientists at the Icahn School of Medicine at Mount Sinai. The discovery may help scientists better understand a range of […]