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RNA Accumulation In Neurons – An Unusual Hallmark Of Aging

As we age, neurons in our brains can become damaged by free radicals. Massachusetts Institute of Technology biologists have now discovered that this type of damage, known as oxidative stress, produces an unusual pileup of short snippets of RNA in some neurons. This RNA buildup, which the researchers believe may be a marker of neurodegenerative […]

Alternative RNA Splicing Occurs More Frequently In Tumors

New cancer-specific molecular changes that could potentially inform the development of cancer treatments have been uncovered by scientists at ETH Zurich. A research team led by Gunnar R├Ątsch, Professor of Biomedical Informatics at ETH Zurich, evaluated the largest set of genetic data in cancer medicine: The Cancer Genome Atlas. The Atlas compiles genetic information on […]

Network Of Diverse Noncoding RNAs Acts In The Brain

Scientists at MIT’s Whitehead Institute have identified a highly conserved network of noncoding RNAs acting in the mammalian brain. While gene regulatory networks are well described, this is the first documented regulatory network comprised of three types of noncoding RNA: microRNA, long noncoding RNA, and circular RNA. The finding expands our understanding of how several […]

Molecular Hallmarks Of Motor Neuron Death In ALS Identified

A protein known as Splicing Factor, proline- and glutamine-rich (SFPQ), which normally resides inside the cell nucleus, exits the nucleus in diseased motor neurons, a new study from The Francis Crick Institute shows. The finding is the result of a collaborative group of clinical neurologists, molecular biologists and computer scientists working together to solve the […]

Paupar RNA Regulates Olfactory Bulb Neurogenesis

A non-coding RNA, called Paupar (PAX6 Upstream Antisense RNA), which influences how healthy brains develop during early life, has been identified by scientists from the Universities of Edinburgh, Bath, and Oxford. They have shown that Paupar orchestrates proteins that control neurodevelopment. Since the human genome was first sequenced in 2001, scientists have puzzled over swathes […]