A fusion gene is a new gene made by joining parts of two different genes. The current thought is that fusion genes can happen in cells with unstable genome when part of the DNA from one chromosome moves to another chromosome. When the fusion gene is transcribed into RNA, the product is a fusion RNA… Read more

A potential new biomarker and drug target for amyotrophic lateral sclerosis has been identified by research led by stem cell scientists at Harvard University. The study used stem cell models of human motor neurons to reveal the gene STMN2 as a potential therapeutic target, demonstrating the value of this human stem cell model approach in… Read more

As we age, neurons in our brains can become damaged by free radicals. Massachusetts Institute of Technology biologists have now discovered that this type of damage, known as oxidative stress, produces an unusual pileup of short snippets of RNA in some neurons. This RNA buildup, which the researchers believe may be a marker of neurodegenerative… Read more

New cancer-specific molecular changes that could potentially inform the development of cancer treatments have been uncovered by scientists at ETH Zurich. A research team led by Gunnar R├Ątsch, Professor of Biomedical Informatics at ETH Zurich, evaluated the largest set of genetic data in cancer medicine: The Cancer Genome Atlas. The Atlas compiles genetic information on… Read more

Scientists at MIT’s Whitehead Institute have identified a highly conserved network of noncoding RNAs acting in the mammalian brain. While gene regulatory networks are well described, this is the first documented regulatory network comprised of three types of noncoding RNA: microRNA, long noncoding RNA, and circular RNA. The finding expands our understanding of how several… Read more