RNA Editing Reduced In Brains From Autistic Individuals

dna mutation
Important clues to what goes wrong in the brains of people with autism have been found by A team of UCLA-led scientists. The new insights involve RNA editing — in which genetic material is normal, but modifications in RNA alter nucleotides, whose patterns carry the data required for constructing proteins. "RNA editing is probably having …

STMN2 Gene A Potential Therapeutic Target For ALS

ALS-implicated protein TDP-43
A potential new biomarker and drug target for amyotrophic lateral sclerosis has been identified by research led by stem cell scientists at Harvard University. The study used stem cell models of human motor neurons to reveal the gene STMN2 as a potential therapeutic target, demonstrating the value of this human stem cell model approach in …

RNA Accumulation In Neurons – An Unusual Hallmark Of Aging

rna snippet accumulation
As we age, neurons in our brains can become damaged by free radicals. Massachusetts Institute of Technology biologists have now discovered that this type of damage, known as oxidative stress, produces an unusual pileup of short snippets of RNA in some neurons. This RNA buildup, which the researchers believe may be a marker of neurodegenerative …

Alternative RNA Splicing Occurs More Frequently In Tumors

Alternative Splicing Across Tumors
New cancer-specific molecular changes that could potentially inform the development of cancer treatments have been uncovered by scientists at ETH Zurich. A research team led by Gunnar Rätsch, Professor of Biomedical Informatics at ETH Zurich, evaluated the largest set of genetic data in cancer medicine: The Cancer Genome Atlas. The Atlas compiles genetic information on …

Network Of Diverse Noncoding RNAs Acts In The Brain

regulatory RNA
Scientists at MIT's Whitehead Institute have identified a highly conserved network of noncoding RNAs acting in the mammalian brain. While gene regulatory networks are well described, this is the first documented regulatory network comprised of three types of noncoding RNA: microRNA, long noncoding RNA, and circular RNA. The finding expands our understanding of how several …

Molecular Hallmarks Of Motor Neuron Death In ALS Identified

hippocampal neurones
A protein known as Splicing Factor, proline- and glutamine-rich (SFPQ), which normally resides inside the cell nucleus, exits the nucleus in diseased motor neurons, a new study from The Francis Crick Institute shows. The finding is the result of a collaborative group of clinical neurologists, molecular biologists and computer scientists working together to solve the …