retroviruses

With nearly two million new infections and one million associated deaths each year, the HIV (human immunodeficiency virus) pandemic is alive and well. Thirty-seven million people are now living with HIV, more than half of whom are women. Today, most HIV transmission occurs through sex. Fortunately, you can protect yourself and others by keeping HIV… Read more

Specific interactions that occur between the HIV virus capsid and a key protein that interferes with the protective shell’s integrity have been identified in a new study. The findings are just one step in better understanding the mechanism of HIV infection, but the researchers believe it’s an important advance. “This is basic science, fundamental research… Read more

A new drug called URMC-099 extends the effectiveness of multiple HIV therapies by unleashing a cell’s own protective machinery on the virus. The finding is an important step toward the creation of long-acting HIV drugs that could be administered once or twice per year, unlike current HIV treatments that need to be taken every day… Read more

The mechanism by which HIV is able to infect macrophages, a type of white blood cell integral to the immune system, despite the presence of a protective protein, has been identified by a team led by researchers at University College London. They discovered a treatment that can maintain macrophage defences, which could be a key… Read more

The atomic structure of a key piece of machinery that allows HIV to integrate into human host DNA and replicate in the body has been solved by Salk Institute scientists. The findings describing this machinery, known as the “intasome,” which has eluded researchers for decades, yield structural clues informing the development of new HIV drugs… Read more