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Peptide Immunotherapy Shows Promise In Type 1 Diabetes

There may be the potential to ‘retrain’ the immune system to slow the progression of type 1 diabetes, according to results of a new clinical trial. Researchers leading the MonoPepT1De trial at King’s College London and Cardiff University observed noticeable changes in the behavior of the immune systems of type 1 diabetes patients that had […]

C9orf72 Protein Aggregation Pathway For Neurodegeneration

New processes for forming protein clumps that are characteristic of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) have been identified by scientists from Belgium, the UK and the US. How these proteins, which can bind RNA in normal cells, stick together has remained elusive until recently, when scientists demonstrated that they de-mix from […]

Molecular Peptide Vectors Emerging Paradigm For Blood-brain Barrier Delivery

A new class of drug transporters have the capacity to reach the brain more efficiently, fusing chemistry, pharmacy and biomedicine, say researchers. IRB Barcelona scientists Benjamí Oller, Macarena Sánchez, Ernest Giralt, and Meritxell Teixidó, all from the Peptides and Proteins Lab of the Chemistry and Molecular Pharmacology Program, have authored a review on the emerging […]

Lipid-like Peptoid Mimics Cell Membranes

Materials scientists have developed a new material that performs like a cell membrane found in nature. Such a material has long been sought for applications as varied as water purification and drug delivery. Referred to as a lipid-like peptoid, the material can assemble itself into a sheet thinner, but more stable, than a soap bubble, […]

Missing Tooth Hydrogel Eases Insoluble Drug Delivery

Bioengineers at Rice University have created a gap-toothed peptide that may be an efficient way to deliver insoluble drugs to precise locations in the body. Rice bioengineer Jeffrey Hartgerink and his students made a hydrogel of what they call “missing tooth” peptide nanofibers. Gaps in the fibers are designed to hold drug molecules that have […]