Vasomotion, the spontaneous oscillation in tone of blood vessel walls, independent of heart beat, innervation or respiration, pushes the clearance of substances from the brain, investigators at Massachusetts General Hospital (MGH) have found. The findings suggest that targeting and enhancing this process may promote prevention or treatment of amyloid-beta accumulation. In Alzheimer’s disease, amyloid-beta protein… Read more

MIT engineers have developed a magnetically steerable, thread-like robot that can actively glide through narrow, winding pathways, such as the labrynthine vasculature of the brain. In the future, this robotic thread may be paired with existing endovascular technologies, enabling doctors to remotely guide the robot through a patient’s brain vessels to quickly treat blockages and… Read more

A potential approach to treating small vessel disease, one of the commonest causes of dementia and stroke in older people, has been uncovered by a team of scientists led by the University of Edinburgh. Studies with rats found the treatment can reverse changes in blood vessels in the brain associated with the condition. Treatment also… Read more

A research team from Nanjing, China has discovered neuroprotective effects from catalpol, a root extract which has previously been shown to have anti-oxidative properties. The group created a blood-brain barrier in the lab and used amyloid-beta peptide to induce damage before treating the cells with catalpol. They established that catalpol protects brain endothelial cells from… Read more

A research team from Johns Hopkins University in the USA have recreated human brain-microvessels within the lab. This is important as replicating brain-microvessels and the blood-brain barrier is crucial to studying both healthy function of brain blood vessels and the function and mechanisms of this in disease. Multiple diseases affect the blood vessels of the… Read more