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Crystal Structure For Neuropeptide Y Receptor Determined

Researchers have characterized a complex, little-understood receptor type that, when activated, shuts off hunger. The findings may open up opportunities to fight obesity at the cellular level. Jens Meiler, of Vanderbilt University, says pharmaceutical companies have long attempted to develop a small-molecule drug that can do just that. But until now, nobody knew exactly what […]

Neuropeptide Receptor Secrets Uncovered In Atomic Level Images

Atomic level x-ray crystallography images were used by NIH scientists to show how the neuropeptide hormone neurotensin might activate its receptors. The description is the first of its kind for a neuropeptide-binding G protein-coupled receptor (GPCR), a class of receptors involved in a wide range of disorders, and the target of many drugs. Binding to […]