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Silicon Probe Records Neural Activity Across Multiple Brain Regions

A new technology for monitoring neural activity allows scientists to simultaneously follow the nervous system’s cellular conversations at hundreds of different sites within the brain. The new probes are expected to give scientists a much clearer picture of how different parts of the brain work together to process information. The $5.5 million collaboration led by […]

Cytoplasmic Ubiquitin Signaling Network Suppresses Synapse Formation

A variation of a gene linked to autism influences how neurons connect and communicate with each other in the brain, according to a study from Washington University School of Medicine in St. Louis. Mice that lack the gene form too many connections between neurons and have learning problems. The findings suggest that some of the […]

Alzheimer’s Disease Driven By Wnt-PCP: Derailed By Fasudil

A recent multi-centre study has established that synapse loss in Alzheimer’s disease is driven by a specific signalling pathway. This pathway is called the Wnt-planar cell polarity (PCP) signalling pathway and it may be pivotal to the progressive neurodegeneration seen in the disease. The researchers also discovered that this process can be inhibited by the […]

Gelatin Restores Blood-brain Barrier Function After Brain Injury

Researchers from Lund University in Sweden have established beneficial effects of gelatin following brain injury. Gelatin coatings have been used previously on neurological implants due to their inherent ability to reduce damaging immune responses and improve recovery, but the mechanisms underlying this have remained unknown. The group found that gelatin aided recovery of the blood-brain […]

D-mino: Coupling Of Two Drugs Treats Neuro-Inflammation

Researchers from Johns Hopkins University in Baltimore have coupled (conjugated) two drugs to more effectively treat brain inflammation. The coupled drug (D-mino) is able to cross the blood-brain barrier to target inflammation mediated by the brain’s resident immune cells, microglia. Inflammation is a common component of most diseases, and is believed to be critical for […]