neurodegenerative disease

The protein β-arrestin-2 increases the accumulation of neurotoxic tau tangles, a cause of several forms of dementia, by interfering with removal of excess tau from the brain, a new study from the University of South Florida Health (USF Health) Morsani College of Medicine reports. The USF Health researchers discovered that a form of the protein… Read more

Aging-related changes in a class of immune cell known as group 2 innate lymphoid cells (ILC2s) could allow doctors to combat the effects of aging on the brain, researchers at Albany Medical College in New York have found. Their study suggests that targeting these cells might reduce age-related cognitive decline and combat aging-associated neurodegenerative disease… Read more

A new screening platform, developed by scientists at Scripps Research, enables researchers for the first time to rapidly test “libraries” of thousands of molecules to find those that provide broad protection to mitochondria in neurons. Mitochondrial damage is increasingly recognized as a major factor, and in some cases a cause, for diseases of neuronal degeneration… Read more

All neurodegenerative diseases have a common thread: the appearance of protein clumps in the brain such as amyloid-beta plaques in Alzheimer’s disease and alpha-synuclein aggregates in Parkinson’s. The root cause of this buildup has been hard to pinpoint, but Rockefeller scientists have identified a likely culprit that opens up a new avenue for developing treatments… Read more