A unique pattern of DNA damage that arises in brain cells derived from individuals with a macrocephalic form of autism spectrum disorder (ASD) has been uncovered by researchers at the Salk Institute. The finding helps explain what might go awry in the brain during cell division and development to cause the disorder. “Division, or replication… Read more

A key role for cellular senescence, particularly in astrocytes, in excitotoxicity, which may lead to neurodegeneration, is suggested in research from the Buck Institute. “This study gets to the underlying mechanisms that drive the toxicity. We have identified targets that may be of more use in drug development,” said senior author and Buck professor Judith… Read more

The anti-depressant Prozac (Fluoxetine) could be repurposed to take on one of the deadliest childhood tumours and possibly other types of cancer, scientists said. The breakthrough, led by Brunel University London, could spare young patients treatment with highly toxic cocktails of chemotherapy drugs and radiation. “Prozac has the potential to be used in children with… Read more

Structural differences in the brains of children whose parents have depression have been uncovered in the largest brain imaging study of children ever conducted in the United States[1]. Researchers analyzed brain images from over 7,000 children participating in the Adolescent Brain Cognitive development (ABCD) study, led by the NIH. About one-third of the children were… Read more

Listening To Ketamine

At 32, Raquel Bennett was looking for a reason to live. She’d struggled with severe depression for more than a decade, trying multiple antidepressants and years of talk therapy. The treatment helped, but not enough to make it seem worth living with a debilitating mental illness, she says. “I was desperate.” In 2002, following a… Read more