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Self-assembling Protein Nanocages For Cellular Cargo Delivery

Blueprints that direct human cells to assemble a virus-like delivery system for transporting custom cargo from one cell to another have been developed by scientists from the University of Utah and University of Washington. The work is a step toward a nature-inspired means for delivering therapeutics directly to specific cell types within the body. Wesley […]

Self-Assembled DNA Single Electron Nanoelectronics

A method to fabricate electronic devices by using DNA has been demonstrated by researchers at the Nanoscience Center (NSC) of the University of Jyväskylä and BioMediTech (BMT) of the University of Tampere. DNA itself has no part in the electrical function, but acts as a scaffolding for a linear, pearl-necklace-like nanostructure consisting of three gold […]

Protein Icosahedra Nanocages Could Improve Drug Delivery

Employing unique biochemical and computational methods, scientists have designed and built large protein icosahedra (polyhedra with 20 faces) similar to viral capsids that carry viral DNA. The designed structures are made of two different engineered proteins, present in 60 copies each, which self-assemble into icosahedra. They have a wide variety of potential applications, from targeted […]

Elastic Energy Partitioning In DNA Deformation

Knowledge of how DNA folds and bends could offer new perspective on how it is handled within cells while also aiding in the design of DNA-based nano-scale devices, says a biomedical engineer at Texas A&M University whose new motion-based analysis of DNA is providing an accurate representation of the molecule’s flexibility. The model, which is […]

DNA Origami Nanostructures Smuggle Drugs Into Cancer Cells

Researchers at The Ohio State University are working on a new way to treat drug-resistant cancer that the ancient Greeks would approve of— only it’s not a Trojan horse, but DNA that hides the invading force. In this case, the invading force is a common cancer drug. In laboratory tests, leukemia cells that had become […]