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Tag: Molecular Psychiatry

Gene Mutation Ties Mitochondrial Disease To Bipolar Disorder

Mutations in the gene ANT1 may raise risk for bipolar disorder through a complex interplay between serotonin and mitochondrial signaling in the brain. These two pathways have been separately implicated in bipolar disorder, but the link between levels of the neurotransmitter serotonin and mitochondrial dysfunction had not been established. Researchers at the RIKEN Center for […]

Cognitive Impairments Reversed In Mouse Tauopathy Model

Tau pathology — the second-most important lesion in the brain in patients with Alzheimer’s disease — can be reversed by a drug, new research from Temple University suggests. Reversing memory deficits and impairments in spatial learning is a major goal in the field of dementia research. A lack of knowledge about cellular pathways critical to […]

Transcription Factor Potential New Depression Treatment Target

A new mechanism involved in depression has been identified by a team of scientists at McGill University and France’s Institut national de la santé et de la recherche médicale (INSERM). More importantly, they also discovered a way to target it with a drug as effective as classical antidepressants. The results of the study, which investigated […]

Anticholinergic Drugs Linked With Increased Risk Of Dementia

Use of anticholinergic drugs, is associated with increased risk of dementia, even when taken 20 years before diagnosis of cognitive impairment, a large study has found. Anticholinergics are a class of drugs commonly prescribed in the United States and United Kingdom as antidepressants and incontinence medications. An international research team from the US, UK and […]

Crystal Structure For Neuropeptide Y Receptor Determined

Researchers have characterized a complex, little-understood receptor type that, when activated, shuts off hunger. The findings may open up opportunities to fight obesity at the cellular level. Jens Meiler, of Vanderbilt University, says pharmaceutical companies have long attempted to develop a small-molecule drug that can do just that. But until now, nobody knew exactly what […]