molecular neurology

Evidence that a common neurotransmitter can selectively regulate the excitability of neurons has been uncovered by an international research collaboration. The researchers were investigating gamma-aminobutyric acid, known as GABA, the primary inhibitory neurotransmitter in the human brain. “We were using computer models from the Blue Brain Project, which predicted that GABA could be having two… Read more

As neuroscientists, we use these three-dimensional clusters of cells grown in petri dishes to learn more about how the human brain works. Researchers culture various kinds of organoids from stem cells – cells that have the potential to become one of many different cell types found throughout the body. We use chemical signals to direct… Read more

Chaperone proteins in human cells cooperate dynamically with α-Synuclein, a protein strongly associated with Parkinson’s disease. A disrupted relationship to these “bodyguards” leads to cell damage and the formation of Lewy bodies typical for Parkinson’s, researchers from the University of Basel’s Biozentrum report. The assisting proteins, known as chaperones, are constantly protecting α-Synuclein in human… Read more

N-acetylcysteine (NAC) is a naturally occurring molecule that replenishes one of the body’s antioxidants and now shows potential benefit as part of a standard course of treatment for patients with Parkinson’s disease, according to a new study. The study found improvements in dopamine levels, the primary neurotransmitter that is specifically decreased in Parkinson’s disease, as… Read more

Neuron development is often regulated by the graded distribution of guidance molecules, which can either attract or repel the neuronal migration or neurite projection when presented in a format of concentration gradients, or chemotaxis. However, many details about the process are largely unexplored. A research team from City University of Hong Kong (CityU) has tackled… Read more