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Alzheimer’s Progression Linked To Aberrant Pre-mRNA Splicing

Specific RNA splicing events associated with Alzheimer’s disease progression have been identified in a large-scale analysis of RNA from postmortem human brain tissue. Researchers at the Icahn School of Medicine at Mount Sinai and Columbia University presented a comprehensive genome-wide map of RNA splicing variation in the aging prefrontal cortex that will serve as a new […]

MicroRNA Snippets Could Help In Early Alzheimer’s Detection

Tiny snippets of genetic material called microRNA may offer a way to detect conditions such as Alzheimer’s disease earlier, according to a new study. Researchers have discovered that changes in microRNA are detectable in mice long before they start to show symptoms from neurodegeneration. The changes may represent an early warning sign, or “biomarker,” for […]

RNA Modification Controls Embryonic Brain Development

A chemical tag added to create RNA modification during embryonic development controls how the early brain grows, new research from the Perelman School of Medicine at the University of Pennsylvania has revealed. In the last few years, scientists have discovered chemical modifications to messenger RNA (mRNA) across the genome at certain sites and found that […]

MicroRNAs Protect Neuron Progenitors From Programmed Cell Death

MicroRNAs protect the precursors of neurons from programmed cell death, new research from Ludwig-Maximilians-Universitaet (LMU) in Munich shows. Programmed cell death, known as apoptosis, is a fundamental and tightly regulated process that occurs in all higher organisms. For example, it is essential to normal embryonic development, during which superfluous cells must be disposed of in […]