Specific RNA splicing events associated with Alzheimer’s disease progression have been identified in a large-scale analysis of RNA from postmortem human brain tissue. Researchers at the Icahn School of Medicine at Mount Sinai and Columbia University presented a comprehensive genome-wide map of RNA splicing variation in the aging prefrontal cortex that will serve as a new… Read more

Tiny snippets of genetic material called microRNA may offer a way to detect conditions such as Alzheimer’s disease earlier, according to a new study. Researchers have discovered that changes in microRNA are detectable in mice long before they start to show symptoms from neurodegeneration. The changes may represent an early warning sign, or “biomarker,” for… Read more

A chemical tag added to create RNA modification during embryonic development controls how the early brain grows, new research from the Perelman School of Medicine at the University of Pennsylvania has revealed. In the last few years, scientists have discovered chemical modifications to messenger RNA (mRNA) across the genome at certain sites and found that… Read more

Each time you swallow food, cells that line your intestines must step up their activity in a sudden and dramatic manner. In fact, they rise to the challenge in the most economic fashion, according to a new study by Weizmann Institute of Science researchers. In economics or engineering, when one has to get production ramped-up… Read more

MicroRNAs protect the precursors of neurons from programmed cell death, new research from Ludwig-Maximilians-Universitaet (LMU) in Munich shows. Programmed cell death, known as apoptosis, is a fundamental and tightly regulated process that occurs in all higher organisms. For example, it is essential to normal embryonic development, during which superfluous cells must be disposed of in… Read more