Trillions of bacteria, fungi and viruses live inside us, forming what is known as our microbiota. Far from causing problems, these microbes benefit our health in many ways. Most of our microbiota lives in our gut, yet there is increasing evidence that it can influence how our central nervous system works. Gut microbes produce compounds… Read more

An existing technique has been adapted to study the melting behaviour of proteins so that it can be used for the study of bacteria. Thermal proteome profiling (TPP) was developed in 2014 (Savitski et al., Science 2014) and enables scientists to compare the melting behavior of all proteins in a cell or organism before and… Read more

Gut microbes facilitate production and secretion of digestive enzymes into the small bowel, according to a new study. The majority of research on the gut microbiome has focused on bacteria in the large intestine, but this study — one of a few to concentrate on microbes in the upper gastrointestinal tract — shows how the… Read more

Bacteria in the small intestines can travel to other organs and trigger an autoimmune response, a new Yale study indicates. The researchers also found that the autoimmune reaction can be suppressed with an antibiotic or vaccine designed to target the bacteria. The findings suggest promising new approaches for treating chronic autoimmune conditions, including systemic lupus… Read more

A molecular process that can lead to neurodegeneration in patients with HIV has been identified and inhibited, reports a Northwestern University Medicine study. Previous studies have found elevated levels of toxic beta-amyloid protein in the brains of patients with human immunodeficiency virus (HIV), causing HIV-associated neurocognitive disorder (HAND). While combination antiretroviral therapy can greatly slow… Read more