Chloroquine, a drug currently used to treat malaria, may be useful in treating patients with metastatic cancers, a new study by University of Kentucky Markey Cancer Center researchers shows. The study found that chloroquine induced the secretion of the tumor suppressor protein Par-4 in both mouse models and in cancer patients in a clinical trial… Read more

One thing that makes cancer so lethal is its ability to move. The better that doctors are able to keep tumors contained and protect unaffected organs in the body, the less lethal a cancer will be. And if doctors were actually able to pinpoint tumor cells and literally stop them in their tracks, it would… Read more

A specific protein called CD36 has been identified on cancer cells which have the ability to metastasize. CD36, found in the cell membranes of tumor cells, is responsible for taking up fatty acids. This unique CD36 activity and dependence on fatty acids distinguishes metastasis-initiating cells from other tumor cells. The team of scientists, headed by… Read more

Cancer cells seem to rely on a novel survival mechanism to metastasize, an early study led by Queen Mary University of London (QMUL) has found. The discovery could help with future development of novel treatments to prevent metastasis and secondary tumors. Metastasis, the spread of cancer around the body, is one of the biggest challenges… Read more

A molecular key that breast cancer cells use to invade bone marrow has been identified in mice by scientists at the Duke Cancer Institute. Once inside the marrow, they can be protected from chemotherapy or hormonal therapies that could otherwise eradicate them. Through years of experiments in mice, the scientists have found ways to outmaneuver… Read more