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Neutrophil Extracellular Traps Awaken Sleeping Cancer Cells

A mechanism by which cancers in remission can spring back into action has been identified by scientists at Cold Spring Harbor Laboratory (CSHL). The knowledge has inspired a new treatment idea designed to prevent cancer recurrence and metastasis. Even after successful cancer treatment, dormant, non-dividing cancer cells that previously detached from the original tumor may […]

Alternative RNA Splicing Occurs More Frequently In Tumors

New cancer-specific molecular changes that could potentially inform the development of cancer treatments have been uncovered by scientists at ETH Zurich. A research team led by Gunnar R├Ątsch, Professor of Biomedical Informatics at ETH Zurich, evaluated the largest set of genetic data in cancer medicine: The Cancer Genome Atlas. The Atlas compiles genetic information on […]

Mutated Lung Cancer Cells Resemble Intestinal Cells

Certain lung cancer cells with errors in transcription factors begin to resemble their nearest relatives, the cells of the stomach and gut, new research from Duke University has found. Tumors are notoriously mixed up; cells from one part often express different genes and adopt different sizes and shapes than cells from another part of that […]

Long Noncoding RNA Based Oncogenic Drivers Identified

633 new biomarkers for 14 types of cancer have been identified in an extensive research project at Sahlgrenska Academy, Sweden. Additionally, by dampening the activity of a specific RNA molecule, the researchers have cured lung tumors in mice by 40-50 percent. The research group, led by Chandrasekhar Kanduri, professor of Medical Biochemistry and Cell Biology, […]

Human Organ Chip Models Lung Cancer Growth & Drug Response

Human orthotopic lung cancer models have been developed by a team at the Wyss Institute, using two microfluidic devices. For today’s cancer researchers, generating human tumours in mice by injecting cancer cell lines under the skin does not recreate how tumours normally emerge and spread to specific organs in the human body, nor how they […]