A High-definition Map Of Liver Cells In Health And Disease

Liver Cells
Researchers have created a high-resolution picture of the cells at work inside a key hub of metabolism — the liver — and shown how disease reprograms individual cell types. In every tissue throughout our bodies, various cell types communicate and coordinate their efforts to perform vital functions and maintain health. The new research not only …

Altered Liver Enzymes Associated With Biomarkers For Alzheimer’s Disease

AD liver
Novel connections between liver dysfunction and Alzheimer's disease have been identified in research from the Alzheimer's Disease Metabolomics Consortium (ADMC) and Alzheimer's Disease Neuroimaging Initiative (ADNI). The study, was led by IU School of Medicine radiology professor Kwangsik Nho, Ph.D. and explores the relationship between blood-based biochemical markers of liver function and established Alzheimer's disease …

Liver Transplants Could Be Unnecessary With Discovery Of New Liver Cell

cytoarchitectural changes found in a liver
A type of cell that may be able to regenerate liver tissue has been identified by King's College London researchers. Treating liver failure without the need for transplants could be a potential application. The scientists have identified a new type of cell called a hepatobiliary hybrid progenitor (HHyP), that forms during our early development in …

High Fat Diet Has Long-lasting Effects On The Liver

hamburger
Eating a diet high in fat and sugar causes a harmful accumulation of fat in the liver that may not reverse even after switching to a healthier diet, according to a new study by scientists from Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center. The investigators developed a nanosensor that can detect and noninvasively …

SALL4 Targeting Peptide Could Stop Hepatocellular Carcinoma

A new drug called FFW that could potentially stop the development of hepatocellular carcinoma or primary liver cancer has been developed by scientists at the Cancer Institute of Singapore. The discovery opens the door for more effective treatments with fewer side effects. Hepatocellular carcinoma (HCC) is a fast-growing cancer of the liver, and patients typically …

Thyroid Hormone Shows Promise For Fighting NAFLD

labware
A thyroid hormone shows promise in fighting non-alcoholic fatty liver disease (NAFLD) in patients with diabetes, according to new research. The disease, a major global health problem characterized by accumulation of fat in the liver, develops in patients with obesity, type 2 diabetes, dyslipidaemia, and insulin resistance. The presence of excess fat in the liver …

T-Cell Therapy Liver Cancer Treatment Trial Early Results Promising

cytoarchitectural changes found in a liver
Although unparalleled clinical efficacy has been achieved using chimeric antigen receptor (CAR) redirected T cells to treat liquid malignancies, such as B-cell hematologic tumors, their use against solid tumors has faced many challenges. Now, a favorable safety profile of an experimental T-cell therapy for liver cancer has been announced at the 2018 CAR-TCR Summit in …