inflammatory diseases

Researchers have struggled for years to understand how mutations in one gene, called LRRK2, can increase the risk of three very different diseases: Parkinson’s (a brain disease), Crohn’s (a gut disease) and leprosy (a peripheral nervous system disease). Now, a Canadian team has found that inflammation is the likely culprit. “Everyone thought that LRRK2’s primary… Read more

Chronic fatigue syndrome is associated with variations in 17 immune-system signaling proteins whose concentrations in the blood correlate with the disease’s severity, new research suggests. The findings provide evidence that inflammation is a powerful driver of this mysterious condition, whose underpinnings have eluded researchers for 35 years. The study results could lead to further understanding… Read more

Researchers have custom built two molecules which bind to and inhibit enzymes called tankyrases that are involved in an important cellular process called Wnt/β-catenin signalling. The research team from Cancer Research at University of Bath, working with colleagues at the University of Oulu in Finland, hope these new molecules could one day become drugs for… Read more

Consuming cruciferous vegetables, such as broccoli, kale, cabbage and cauliflower, helps the immune system to fight intestinal pathogens, a recent study in mice shows. The finding could have implications for people with inflammatory bowel diseases. A protein known as the aryl hydrocarbon receptor (AhR) plays a critical role in protecting us from external pollutants, toxins… Read more

New links between the human genome and inflammation tracers have been found by researchers in Finland. In a study of over ten million DNA variations, new possibilities for treatment of diseases such as multiple sclerosis, Crohn’s disease and celiac disease were uncovered. Researchers at the Research Centre of Applied and Preventive Cardiovascular Medicine at the… Read more