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Tag: Huntington’s

Apathy Is A Biomarker Of Huntington’s Disease Progression

Alterations in the connectivity of cerebral white matter associated with the diverse nature of apathy in Huntington’s disease have been identified by researchers[1]. The finding suggest a potential use of this syndrome as a biomarker of disease progression, and may lead to personalized treatments for apathy as a multidimensional syndrome in other neurodegenerative disorders. “Our […]

Brain Urea Buildup Found To Be A Major Cause Of Dementia

The build-up of urea in the brain to toxic levels can cause brain damage, and eventually dementia, an international team of scientists has discovered. The finding, of a major cause of dementia, has important implications for possible treatment and diagnosis. The work follows on from earlier studies, led by professor Garth Cooper from The University […]

Early Or Late Onset of Huntington’s Disease Depends on Gene Variant

A gene variant that influences whether Huntington’s disease breaks out earlier or later than expected has been discovered. The findings could contribute to improved diagnosis and disease-modifying therapies. Huntington’s disease is an inherited and progressive neurodegenerative disease. A typical symptom is involuntary movements. While the symptom normally debuts in middle-age, there is wide individual variation […]

Major Vascular Changes Found In Brains Of People With Huntington’s Disease

Significant vascular changes in the brains of people with Huntington’s disease have been identified in an international study led by researchers from Université Laval and CHU de Québec-Université Laval The breakthrough will have significant implications for our understanding of the disease and could be the key to new therapeutic targets for treating this fatal neurodegenerative […]

Locked Signal Receptors May Lead To Neurodegeneration

The IP3R receptor ia a cell receptor broadly involved in intracellular calcium signaling. Researchers have now found that the receptor can be locked into a closed state by enzyme action, and that this locking may potentially play a role in the reduction of neuron signaling seen in neurodegenerative diseases such as Huntington disease and Alzheimer’s […]