Huntington’s disease

An overlap between the causes of rheumatoid arthritis and Huntington’s disease, a fatal and incurable genetic brain disease, has been found by researchers at University of California San Diego School of Medicine and the Icahn School of Medicine at Mount Sinai. Using new analytic tools, the researchers decoded the epigenetic landscape for rheumatoid arthritis (RA)… Read more

“It came completely out of the blue,” says James*. They had thought it was his father’s knees that were the problem – he was never comfortable and was constantly shifting them. “He went to the doctor, and he said, ‘You have got osteoarthritis.’ So that was put to bed for a few months.” But that… Read more

A natural mechanism, which not only suppresses the build-up of pathogenic amyloid fibrils in Huntington’s disease, but also disaggregates them, has been uncovered by a team of scientists in Germany. The newly discovered molecular chaperones could soon be crucial parts of new therapy approaches. As of today, Huntington’s disease, like the neurodegenerative diseases named after… Read more

Disruptions in the movement of cellular materials in and out of a cell’s control center — the nucleus — appear to be a direct cause of brain cell death in Huntington’s disease, Johns Hopkins researchers report. They also say laboratory experiments with drugs designed to clear up these cellular “traffic jams” restored normal transport in… Read more

Teva Pharmaceutical’s deutetrabenazine has been given the green light by the U.S. Food and Drug Administration for the treatment of chorea associated with Huntington’s disease. Chorea refers to an abnormal involuntary movement disorder, one of a group of neurological disorders called dyskinesias, and is characterized by brief, semi-directed, irregular movements that are not repetitive or… Read more