Increased Hippocampus Metabolism Early Sign of Alzheimer’s Disease

A metabolic rise in a portion of the brain called the hippocampus is an early stage in the development of Alzheimer’s disease, according to Karolinska Institutet researchers. The revelation opens the door to new potential early intervention strategies. Alzheimer’s disease is the most common type of dementia, affecting approximately 20,000 people in Sweden each year.…

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Hippocampus Neurons Act as Brain Glue For Episodic Memories

The development of novel neuroprosthetic devices to assist patients with memory disorders like dementia and Alzheimer’s disease may be greatly aided by the new understanding that scientists have gained into how the brain stores episodic memories, a form of long-term, conscious memory of a prior experience. The new study, led by the University of Glasgow…

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Hippocampus Place Cells Use Rate And Phase Code For Route Finding

Pyramidal neurons in the hippocampus inscribe spatial information using two interchangeable information processing methods referred to as a rate code and a phase code, that can be roughly compared to the number and spatial arrangement of bar codes, The Korea Institute of Science and Technology (KIST) reports. The research team, led by Sebastien Royer at…

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Early Hippocampus Atrophy At Age 40 In Alzheimer’s Patients Found

Early atrophy of the amygdala and hippocampus at age 40 in patients with Alzheimer’s disease is revealed in new research from Europe. Researchers at the Laboratoire bordelais de recherche en informatique (LaBRI) (CNRS/Bordeaux INP/Université de Bordeaux), at the Aquitaine Institute for Cognitive and Integrative Neuroscience (CNRS/Université de Bordeaux/EPHE) and the University of Valencia (Spain) created…

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Hippocampus Oxytocin Receptors Enable Social Recognition

Representative images of Cre and GFP virus infection in aCA2/CA3. Credit: Tara Raam, et al. CC-BY

Social recognition is regulated by a lattice of oxytocin sensitive neurons in a part of the hippocampus, a seahorse-shaped structure in the brain responsible for memory formation, according to a new study. The research, conducted in mice by regenerative neuroscientists at Harvard Medical School, the Harvard Stem Cell Institute and Massachusetts General Hospital, provides critical…

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Hippocampus, Amygdala Asymmetries May Track Alzheimer's Progression

A unique approach to analyzing brain structure that focuses on the shape instead of the size of features may allow identification of individuals in early pre-symptomatic stages of Alzheimer’s disease. A team of Massachusetts General Hospital (MGH) investigators using advanced computational tools to analyze data from standard MRI scans report that individuals with Alzheimer’s disease,…

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