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Glutamate Binds To AMPA Receptors By Following Preferential Pathways

An atomic scale map that tracks how the signaling chemical glutamate binds to a neuron in the brain has been created by scientists at Johns Hopkins, using supercomputers. The findings shed light on the dynamic physics of the chemical’s pathway, as well as the speed of nerve cell communications. It’s long been known that brain […]

AMPA Glutamate Receptor Action Imaged By Cryo EM

The first three-dimensional snapshots of the AMPA-subtype glutamate receptor in action have been captured, report researchers at Columbia University Medical Center (CUMC). The receptor, which regulates most electrical signaling in the brain, is involved in several important brain activities, including memory and learning. “With our new findings, we can now, for the first time, visualize […]

Lithium May Protect Nerve Cells After Traumatic Brain Injury

A drug used to treat bipolar disorder and other forms of depression may help preserve brain function and prevent nerve cells from dying in people with a traumatic brain injury. Scientists discovered that lithium and rapamycin, a treatment for some forms of cancer, protect nerve cells in the brain and stop the chemical glutamate from […]

Loss Of Astrocytes In Brain May Inhibit Neuronal Development

Shedding light on possible contributors to autism, schizophrenia and other neuro-psychiatric disorders, researchers have found that a type of support cell abundant in the brain may play a role in the ability of neurons to communicate. The team of scientists, at Washington University School of Medicine in St. Louis found, in culture, that without these […]

Why Glutamate Is An Essential Food For The Brain

Glutamate is an amino acid with very different functions. In the pancreas, it modulates the activity of the pancreatic ß-cells responsible for insulin production, whereas in the brain it is the main excitatory neurotransmitter. In recent years, it has been suspected to play an additional role in the functioning of the brain. By discovering how […]