If the immune system attacks its own body, it can often have devastating consequences: autoantibodies bind to the body’s structures, triggering functional disorders. The receptors for glutamate, a neurotransmitter, can also become the target of autoantibodies. Researchers at the Max Planck Institute of Experimental Medicine have been investigating the circumstances under which autoantibodies for a… Read more

The molecules of the neurotransmitter glutamate released when a signal is transferred between two brain cells has been counted, for the first time, by researchers at Chalmers University of Technology and Gothenburg University in Swedenby. With a novel analysis method, they demonstrated that the brain regulates its signals using glutamate in more ways than previously… Read more

An atomic scale map that tracks how the signaling chemical glutamate binds to a neuron in the brain has been created by scientists at Johns Hopkins, using supercomputers. The findings shed light on the dynamic physics of the chemical’s pathway, as well as the speed of nerve cell communications. It’s long been known that brain… Read more

The first three-dimensional snapshots of the AMPA-subtype glutamate receptor in action have been captured, report researchers at Columbia University Medical Center (CUMC). The receptor, which regulates most electrical signaling in the brain, is involved in several important brain activities, including memory and learning. “With our new findings, we can now, for the first time, visualize… Read more

A drug used to treat bipolar disorder and other forms of depression may help preserve brain function and prevent nerve cells from dying in people with a traumatic brain injury. Scientists discovered that lithium and rapamycin, a treatment for some forms of cancer, protect nerve cells in the brain and stop the chemical glutamate from… Read more