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Cracking The Code Of Sonic Hedgehog Medulloblastoma

One of the most common brain cancers in children, Sonic Hedgehog (SHH) medulloblastoma, also is one of the more survivable for most kids. Unfortunately, for a subset of patients the cancer resists treatment and relapses with a vengeance to then turn deadly. Researchers at Cincinnati Children’s Hospital Medical Center used a powerful new computer-assisted technology […]

Computer-assisted Method Helps Diagnose Glioma Tumor Growth

A computer-assisted diagnostic procedure helps physicians detect the growth of low-grade brain tumors earlier and at smaller volumes than visual comparison alone, according to a new study by Hassan Fathallah-Shaykh of the University of Alabama at Birmingham, and colleagues. Additional clinical studies are needed to determine whether early therapeutic interventions enabled by early tumor growth […]

Distinct Transitional States Of Cortex Glial Progenitors Uncovered

A molecular driver of the highly aggressive, deadly, and treatment-resistant brain cancer glioblastoma has been uncovered by scientists, using cell-by-cell genetic analyses of developing brain tissues in neonatal mice and laboratory models of brain cancer. The study identified a subpopulation of cells critical to glioblastoma formation – the early primitive progenitor cells of oligodendrocyte brain […]

Nanoparticle Nasal Spray For Drug Delivery To The Brain

Researchers have developed a noninvasive way to deliver drugs to the brainstem in patients with tumors in that part of the brain. The technique may bring medicine one step closer to curing brain-based diseases such as diffuse intrinsic pontine gliomas (DIPG), a childhood brain cancer with a five-year survival rate of a scant two percent, […]

A Genotype Specific Treatment Approach To Glioma

Glioma, a type of brain cancer, is normally treated by removing as much of the tumor as possible, followed by radiation or chemotherapy. With this treatment, patients survive an average of about 10 years, but the tumors inevitably grow back. A team of researchers from MIT, Brigham and Women’s Hospital, and Massachusetts General Hospital hopes […]